Publications
How to cite / acknowledge the Fondation Campus Biotech Geneva
Authorship:
FCBG adheres to the basic rules of Scientific Integrity regarding authorship of scholar work.
All articles and publications that use any FCBG resources (equipment, protocol assistance and expertise, analyses, …) must have an author directly affiliated with FCBG when the staff member:
- have made an essential contribution to the planning, carrying out, evaluation and verification of the research work;
- have participated in the writing of the manuscript;
- and have approved the final version of the manuscript.
Acknowledgements:
When the FCBG provides a platform contribution (simple data acquisition, assistance in setting up procedures for presentation and collection of behavioral data, etc.), only a sentence in the acknowledgments is needed. For acknowledgements in articles, publications, projects, presentations…, the following text can be added:
“This study was supported by the [XXX] Platform, Fondation Campus Biotech Geneva, Geneva, Switzerland.”
5649449
QWCYR4J9
1
apa
50
default
desc
year
1
29453
https://platforms.fcbg.ch/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A150%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225JS8Y7IV%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A14975604%2C%22username%22%3A%22robuser%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Frobuser%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Beanato%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBeanato%2C%20E.%2C%20Moon%2C%20H.-J.%2C%20Windel%2C%20F.%2C%20Vassiliadis%2C%20P.%2C%20Wessel%2C%20M.%20J.%2C%20Popa%2C%20T.%2C%20Pauline%2C%20M.%2C%20Neufeld%2C%20E.%2C%20De%20Falco%2C%20E.%2C%20Gauthier%2C%20B.%2C%20Steiner%2C%20M.%2C%20Blanke%2C%20O.%2C%20%26amp%3B%20Hummel%2C%20F.%20C.%20%282024%29.%20Noninvasive%20modulation%20of%20the%20hippocampal-entorhinal%20complex%20during%20spatial%20navigation%20in%20humans.%20%3Ci%3EScience%20Advances%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%2844%29%2C%20eado4103.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.ado4103%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.ado4103%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Noninvasive%20modulation%20of%20the%20hippocampal-entorhinal%20complex%20during%20spatial%20navigation%20in%20humans%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Beanato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hyuk-June%22%2C%22lastName%22%3A%22Moon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Windel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%22%2C%22lastName%22%3A%22Vassiliadis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maximillian%20J.%22%2C%22lastName%22%3A%22Wessel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Traian%22%2C%22lastName%22%3A%22Popa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Menoud%22%2C%22lastName%22%3A%22Pauline%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esra%22%2C%22lastName%22%3A%22Neufeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emanuela%22%2C%22lastName%22%3A%22De%20Falco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Steiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Blanke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friedhelm%20C.%22%2C%22lastName%22%3A%22Hummel%22%7D%5D%2C%22abstractNote%22%3A%22Because%20of%20the%20depth%20of%20the%20hippocampal-entorhinal%20complex%20%28HC-EC%29%20in%20the%20brain%2C%20understanding%20of%20its%20role%20in%20spatial%20navigation%20via%20neuromodulation%20was%20limited%20in%20humans.%20Here%2C%20we%20aimed%20to%20better%20elucidate%20this%20relationship%20in%20healthy%20volunteers%2C%20using%20transcranial%20temporal%20interference%20electric%20stimulation%20%28tTIS%29%2C%20a%20noninvasive%20technique%20allowing%20to%20selectively%20neuromodulate%20deep%20brain%20structures.%20We%20applied%20tTIS%20to%20the%20right%20HC-EC%20in%20either%20continuous%20or%20intermittent%20theta-burst%20stimulation%20patterns%20%28cTBS%20or%20iTBS%29%2C%20compared%20to%20a%20control%20condition%2C%20during%20a%20virtual%20reality%5Cu2013based%20spatial%20navigation%20task%20and%20concomitant%20functional%20magnetic%20resonance%20imaging.%20iTBS%20improved%20spatial%20navigation%20performance%2C%20correlated%20with%20hippocampal%20activity%20modulation%2C%20and%20decreased%20grid%20cell%5Cu2013like%20activity%20in%20EC.%20Collectively%2C%20these%20data%20provide%20the%20evidence%20that%20human%20HC-EC%20activity%20can%20be%20directly%20and%20noninvasively%20modulated%20leading%20to%20changes%20of%20spatial%20navigation%20behavior.%20These%20findings%20suggest%20promising%20perspectives%20for%20patients%20suffering%20from%20cognitive%20impairment%20such%20as%20following%20traumatic%20brain%20injury%20or%20dementia.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Transcranial%20temporal%20interference%20stimulation%20allows%20noninvasive%20modulation%20of%20the%20hippocampus%20leading%20to%20better%20navigation.%22%2C%22date%22%3A%2211%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fsciadv.ado4103%22%2C%22ISSN%22%3A%222375-2548%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fsciadv.ado4103%22%2C%22collections%22%3A%5B%22QZJCI396%22%2C%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-31T13%3A16%3A45Z%22%7D%7D%2C%7B%22key%22%3A%22UWXRHFPD%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Meyer%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMeyer%2C%20N.%20H.%2C%20Gauthier%2C%20B.%2C%20Stampacchia%2C%20S.%2C%20Boscheron%2C%20J.%2C%20Babo-Rebelo%2C%20M.%2C%20Potheegadoo%2C%20J.%2C%20Herbelin%2C%20B.%2C%20Lance%2C%20F.%2C%20Alvarez%2C%20V.%2C%20Franc%2C%20E.%2C%20Esposito%2C%20F.%2C%20Morais%20Lacerda%2C%20M.%2C%20%26amp%3B%20Blanke%2C%20O.%20%282024%29.%20Embodiment%20in%20episodic%20memory%20through%20premotor-hippocampal%20coupling.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%281%29%2C%201111.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06757-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06757-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Embodiment%20in%20episodic%20memory%20through%20premotor-hippocampal%20coupling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Heidi%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Stampacchia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliette%22%2C%22lastName%22%3A%22Boscheron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%22%2C%22lastName%22%3A%22Babo-Rebelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jevita%22%2C%22lastName%22%3A%22Potheegadoo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Herbelin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Lance%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Alvarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Franc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Esposito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marilia%22%2C%22lastName%22%3A%22Morais%20Lacerda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Blanke%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-09-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-024-06757-7%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-024-06757-7%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-02T07%3A41%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22NWFI6UH4%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mancini%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMancini%2C%20V.%2C%20Saleh%2C%20M.%20G.%2C%20Delavari%2C%20F.%2C%20Bagautdinova%2C%20J.%2C%20%26amp%3B%20Eliez%2C%20S.%20%282023%29.%20Excitatory%5C%2FInhibitory%20Imbalance%20Underlies%20Hippocampal%20Atrophy%20in%20Individuals%20With%2022q11.2%20Deletion%20Syndrome%20With%20Psychotic%20Symptoms.%20%3Ci%3EBiological%20Psychiatry%3C%5C%2Fi%3E%2C%20%3Ci%3E94%3C%5C%2Fi%3E%287%29%2C%20569%26%23x2013%3B579.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biopsych.2023.03.021%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biopsych.2023.03.021%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Excitatory%5C%2FInhibitory%20Imbalance%20Underlies%20Hippocampal%20Atrophy%20in%20Individuals%20With%2022q11.2%20Deletion%20Syndrome%20With%20Psychotic%20Symptoms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Mancini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Muhammad%20G.%22%2C%22lastName%22%3A%22Saleh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farnaz%22%2C%22lastName%22%3A%22Delavari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jo%5Cu00eblle%22%2C%22lastName%22%3A%22Bagautdinova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Eliez%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.biopsych.2023.03.021%22%2C%22ISSN%22%3A%2200063223%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0006322323011721%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T09%3A06%3A17Z%22%7D%7D%2C%7B%22key%22%3A%22PZ2KKPHY%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Latr%5Cu00e8che%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELatr%26%23xE8%3Bche%2C%20C.%2C%20Mancini%2C%20V.%2C%20Rochas%2C%20V.%2C%20Maeder%2C%20J.%2C%20Cantonas%2C%20L.%20M.%2C%20F%26%23xE9%3Brat%2C%20V.%2C%20Schneider%2C%20M.%2C%20Michel%2C%20C.%20M.%2C%20%26amp%3B%20Eliez%2C%20S.%20%282024%29.%20Using%20transcranial%20alternating%20current%20stimulation%20to%20enhance%20working%20memory%20skills%20in%20youths%20with%2022q11.2%20deletion%20syndrome%3A%20A%20randomized%20double-blind%20sham-controlled%20study.%20%3Ci%3EPsychiatry%20Research%3C%5C%2Fi%3E%2C%20%3Ci%3E335%3C%5C%2Fi%3E%2C%20115835.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.psychres.2024.115835%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.psychres.2024.115835%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Using%20transcranial%20alternating%20current%20stimulation%20to%20enhance%20working%20memory%20skills%20in%20youths%20with%2022q11.2%20deletion%20syndrome%3A%20A%20randomized%20double-blind%20sham-controlled%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caren%22%2C%22lastName%22%3A%22Latr%5Cu00e8che%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Mancini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Rochas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Maeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucia%20M.%22%2C%22lastName%22%3A%22Cantonas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%22%2C%22lastName%22%3A%22F%5Cu00e9rat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maude%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%20M.%22%2C%22lastName%22%3A%22Michel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Eliez%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2205%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.psychres.2024.115835%22%2C%22ISSN%22%3A%2201651781%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0165178124001203%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T09%3A02%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22UGHLVGX9%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liverani%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-08%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiverani%2C%20M.%20C.%2C%20Siffredi%2C%20V.%2C%20Mikneviciute%2C%20G.%2C%20Mazza%2C%20E.%2C%20Ha-Vinh%20Leuchter%2C%20R.%2C%20H%26%23xFC%3Bppi%2C%20P.%20S.%2C%20Borradori%20Tolsa%2C%20C.%2C%20%26amp%3B%20Gentaz%2C%20E.%20%282024%29.%20%26%23x201C%3BVis-%26%23xE0%3B-Vis%20Training%26%23x201D%3B%20to%20Improve%20Emotional%20and%20Executive%20Competences%20in%20Very%20Preterm%20Children%3A%20A%20Pilot%20Study%20and%20Randomised%20Controlled%20Trial.%20%3Ci%3EChildren%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%288%29%2C%20956.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fchildren11080956%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fchildren11080956%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22%5Cu201cVis-%5Cu00e0-Vis%20Training%5Cu201d%20to%20Improve%20Emotional%20and%20Executive%20Competences%20in%20Very%20Preterm%20Children%3A%20A%20Pilot%20Study%20and%20Randomised%20Controlled%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Chiara%22%2C%22lastName%22%3A%22Liverani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Siffredi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greta%22%2C%22lastName%22%3A%22Mikneviciute%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%22%2C%22lastName%22%3A%22Mazza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Russia%22%2C%22lastName%22%3A%22Ha-Vinh%20Leuchter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20Susan%22%2C%22lastName%22%3A%22H%5Cu00fcppi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Borradori%20Tolsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edouard%22%2C%22lastName%22%3A%22Gentaz%22%7D%5D%2C%22abstractNote%22%3A%22Background%5C%2FObjectives%3A%20Premature%20birth%20can%20lead%20to%20socio-emotional%2C%20behavioural%20and%20executive%20problems%20that%20impact%20quality%20of%20life%20and%20school%20performance%20in%20the%20long%20term.%20The%20aim%20of%20this%20pilot%20study%20was%20to%20evaluate%20the%20feasibility%20and%20efficacy%20of%20a%2012-week%20computerised%20training%20called%20Vis-%5Cu00e0-vis%20to%20enhance%20these%20competencies%20in%20a%20cohort%20of%20very%20preterm%20%28VPT%29%20children%20aged%206%20to%209.%20Methods%3A%20This%20pilot%20randomised%20controlled%20trial%20included%2045%20children%20born%20before%2032%20gestational%20weeks.%20Socio-emotional%2C%20behavioural%20and%20executive%20competencies%20were%20evaluated%20at%20three%20time%20points%20using%20computerised%20tasks%2C%20neuropsychological%20tests%20and%20questionnaires.%20Results%3A%20Among%20the%20eligible%20VPT%20children%2C%2020%25%20%28n%20%3D%2045%29%20accepted%20to%20be%20part%20of%20the%20study%2C%20and%2040%25%20%28n%20%3D%2018%29%20dropped%20out.%20Finally%2C%2060%25%20%28n%20%3D%2027%29%20of%20the%20enrolled%20participants%20completed%20the%20study.%20Results%20showed%20a%20significant%20improvement%20in%20emotion%20knowledge%20and%20recognition%20immediately%20after%20the%20completion%20of%20the%20training.%20Conclusions%3A%20Overall%2C%20our%20results%20indicate%20that%20the%20implementation%20of%20this%20type%20of%20computerised%20training%20is%20feasible%2C%20but%20the%20overall%20compliance%20is%20unsatisfactory%20given%20the%20high%20dropout%20rate.%20Nevertheless%2C%20the%20positive%20effect%20of%20the%20training%20on%20emotion%20recognition%20encourages%20further%20exploration%20of%20these%20kinds%20of%20interventions%20to%20prevent%20adverse%20consequences%20in%20children%20born%20too%20soon.%22%2C%22date%22%3A%222024-08-08%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fchildren11080956%22%2C%22ISSN%22%3A%222227-9067%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2227-9067%5C%2F11%5C%2F8%5C%2F956%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T06%3A55%3A44Z%22%7D%7D%2C%7B%22key%22%3A%223494KXQM%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Siffredi%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESiffredi%2C%20V.%2C%20Liverani%2C%20M.%20C.%2C%20Fernandez%2C%20N.%2C%20Freitas%2C%20L.%20G.%20A.%2C%20Borradori%20Tolsa%2C%20C.%2C%20Van%20De%20Ville%2C%20D.%2C%20H%26%23xFC%3Bppi%2C%20P.%20S.%2C%20%26amp%3B%20Ha%26%23x2010%3BVinh%20Leuchter%2C%20R.%20%282024%29.%20Impact%20of%20a%20mindfulness%26%23x2010%3Bbased%20intervention%20on%20neurobehavioral%20functioning%20and%20its%20association%20with%20large%26%23x2010%3Bscale%20brain%20networks%20in%20preterm%20young%20adolescents.%20%3Ci%3EPsychiatry%20and%20Clinical%20Neurosciences%3C%5C%2Fi%3E%2C%20%3Ci%3E78%3C%5C%2Fi%3E%287%29%2C%20416%26%23x2013%3B425.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpcn.13675%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fpcn.13675%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Impact%20of%20a%20mindfulness%5Cu2010based%20intervention%20on%20neurobehavioral%20functioning%20and%20its%20association%20with%20large%5Cu2010scale%20brain%20networks%20in%20preterm%20young%20adolescents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Siffredi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Chiara%22%2C%22lastName%22%3A%22Liverani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Fernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorena%20G.%20A.%22%2C%22lastName%22%3A%22Freitas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Borradori%20Tolsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitri%22%2C%22lastName%22%3A%22Van%20De%20Ville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20Susan%22%2C%22lastName%22%3A%22H%5Cu00fcppi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Russia%22%2C%22lastName%22%3A%22Ha%5Cu2010Vinh%20Leuchter%22%7D%5D%2C%22abstractNote%22%3A%22Aim%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Adolescents%20born%20very%20preterm%20%28VPT%3B%20%3C32%5Cu2009weeks%20of%20gestation%29%20face%20an%20elevated%20risk%20of%20executive%2C%20behavioral%2C%20and%20socioemotional%20difficulties.%20Evidence%20suggests%20beneficial%20effects%20of%20mindfulness%5Cu2010based%20intervention%20%28MBI%29%20on%20these%20abilities.%20This%20study%20seeks%20to%20investigate%20the%20association%20between%20the%20effects%20of%20MBI%20on%20executive%2C%20behavioral%2C%20and%20socioemotional%20functioning%20and%20reliable%20changes%20in%20large%5Cu2010scale%20brain%20networks%20dynamics%20during%20rest%20in%20VPT%20young%20adolescents%20who%20completed%20an%208%5Cu2010week%20MBI%20program.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Neurobehavioral%20assessments%20and%20resting%5Cu2010state%20functional%20magnetic%20resonance%20imaging%20were%20performed%20before%20and%20after%20MBI%20in%2032%20VPT%20young%20adolescents.%20Neurobehavioral%20abilities%20in%20VPT%20participants%20were%20compared%20with%20full%5Cu2010term%20controls.%20In%20the%20VPT%20group%2C%20dynamic%20functional%20connectivity%20was%20extracted%20by%20using%20the%20innovation%5Cu2010driven%20coactivation%20patterns%20framework.%20The%20reliable%20change%20index%20was%20used%20to%20quantify%20change%20after%20MBI.%20A%20multivariate%20data%5Cu2010driven%20approach%20was%20used%20to%20explore%20associations%20between%20MBI%5Cu2010related%20changes%20on%20neurobehavioral%20measures%20and%20temporal%20brain%20dynamics.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Compared%20with%20term%5Cu2010born%20controls%2C%20VPT%20adolescents%20showed%20reduced%20executive%20and%20socioemotional%20functioning%20before%20MBI.%20After%20MBI%2C%20a%20significant%20improvement%20was%20observed%20for%20all%20measures%20that%20were%20previously%20reduced%20in%20the%20VPT%20group.%20The%20increase%20in%20executive%20functioning%2C%20only%2C%20was%20associated%20with%20reliable%20changes%20in%20the%20duration%20of%20activation%20of%20large%5Cu2010scale%20brain%20networks%2C%20including%20frontolimbic%2C%20amygdala%5Cu2010hippocampus%2C%20dorsolateral%20prefrontal%2C%20and%20visual%20networks.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20improvement%20in%20executive%20functioning%20after%20an%20MBI%20was%20associated%20with%20reliable%20changes%20in%20large%5Cu2010scale%20brain%20network%20dynamics%20during%20rest.%20These%20changes%20encompassed%20frontolimbic%2C%20amygdala%5Cu2010hippocampus%2C%20dorsolateral%20prefrontal%2C%20and%20visual%20networks%20that%20are%20related%20to%20different%20executive%20processes%20including%20self%5Cu2010regulation%2C%20attentional%20control%2C%20and%20attentional%20awareness%20of%20relevant%20sensory%20stimuli.%22%2C%22date%22%3A%2207%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Fpcn.13675%22%2C%22ISSN%22%3A%221323-1316%2C%201440-1819%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1111%5C%2Fpcn.13675%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T06%3A52%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22CS6YH3Z9%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Siffredi%20et%20al.%22%2C%22parsedDate%22%3A%222023-07-05%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESiffredi%2C%20V.%2C%20Liverani%2C%20M.%20C.%2C%20Borradori-Tolsa%2C%20C.%2C%20Leuchter%2C%20R.%20H.-V.%2C%20Thiran%2C%20J.-P.%2C%20H%26%23xFC%3Bppi%2C%20P.%20S.%2C%20%26amp%3B%20Fischi-G%26%23xF3%3Bmez%2C%20E.%20%282023%29.%20Cortical%20alterations%20after%20very%20preterm%20birth%20and%20the%20association%20with%20socio-emotional%20abilities%20from%20childhood%20to%20early%20adolescence.%20%3Ci%3ECerebral%20Cortex%3C%5C%2Fi%3E%2C%20%3Ci%3E33%3C%5C%2Fi%3E%2814%29%2C%209117%26%23x2013%3B9129.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcercor%5C%2Fbhad187%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcercor%5C%2Fbhad187%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cortical%20alterations%20after%20very%20preterm%20birth%20and%20the%20association%20with%20socio-emotional%20abilities%20from%20childhood%20to%20early%20adolescence%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Siffredi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Chiara%22%2C%22lastName%22%3A%22Liverani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Borradori-Tolsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Russia%20H%5Cu00e0-Vinh%22%2C%22lastName%22%3A%22Leuchter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Philippe%22%2C%22lastName%22%3A%22Thiran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20S%22%2C%22lastName%22%3A%22H%5Cu00fcppi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elda%22%2C%22lastName%22%3A%22Fischi-G%5Cu00f3mez%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Very%20preterm%20birth%20%28VPT%3B%20%26lt%3B32%5Cu00a0weeks%5Cu2019%20gestation%29%20leads%20to%20a%20situation%20where%20crucial%20steps%20of%20brain%20development%20occur%20in%20an%20abnormal%20ex%20utero%20environment%2C%20translating%20to%20vulnerable%20cortical%20and%20subcortical%20development.%20Associated%20with%20this%20atypical%20brain%20development%2C%20children%20and%20adolescents%20born%20VPT%20are%20at%20a%20high%20risk%20of%20socio-emotional%20difficulties.%20In%20the%20current%20study%2C%20we%20unravel%20developmental%20changes%20in%20cortical%20gray%20matter%20%28GM%29%20concentration%20in%20VPT%20and%20term-born%20controls%20aged%206%5Cu201314%5Cu00a0years%2C%20together%20with%20their%20associations%20with%20socio-emotional%20abilities.%20T1-weighted%20images%20were%20used%20to%20estimate%20signal%20intensities%20of%20brain%20tissue%20types%20in%20a%20single%20voxel%20%28GM%2C%20white%20matter%2C%20and%20cortico-spinal%20fluid%29%20and%20extract%20GM%20concentration%20disentangled%20from%20the%20presence%20of%20partial%20volume%20effects%20%28PVEs%29.%20General%20linear%20model%20analysis%20was%20used%20to%20compare%20groups.%20Socio-emotional%20abilities%20were%20assessed%20and%20associations%20with%20GM%20concentration%20were%20explored%20using%20univariate%20and%20multivariate%20analyses.%20The%20effects%20of%20prematurity%20were%20far-reaching%2C%20with%20intricated%20patterns%20of%20increases%20and%20decreases%20of%20GM%20concentration%20mainly%20in%20frontal%2C%20temporal%2C%20parietal%2C%20and%20cingular%20regions.%20Better%20socio-emotional%20abilities%20were%20associated%20with%20increased%20GM%20concentration%20in%20regions%20known%20to%20be%20involved%20in%20such%20process%20for%20both%20groups.%20Our%20findings%20suggest%20that%20the%20trajectory%20of%20brain%20development%20following%20VPT%20birth%20may%20be%20fundamentally%20distinctive%20and%20impact%20socio-emotional%20abilities.%22%2C%22date%22%3A%222023-07-05%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Fcercor%5C%2Fbhad187%22%2C%22ISSN%22%3A%221047-3211%2C%201460-2199%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fcercor%5C%2Farticle%5C%2F33%5C%2F14%5C%2F9117%5C%2F7192822%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T06%3A49%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22PW5EI5AP%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Siffredi%20et%20al.%22%2C%22parsedDate%22%3A%222023-02-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESiffredi%2C%20V.%2C%20Liverani%2C%20M.%20C.%2C%20Van%20De%20Ville%2C%20D.%2C%20Freitas%2C%20L.%20G.%20A.%2C%20Borradori%20Tolsa%2C%20C.%2C%20H%26%23xFC%3Bppi%2C%20P.%20S.%2C%20%26amp%3B%20Ha-Vinh%20Leuchter%2C%20R.%20%282023%29.%20The%20effect%20of%20mindfulness-based%20intervention%20on%20neurobehavioural%20functioning%20and%20its%20association%20with%20white-matter%20microstructural%20changes%20in%20preterm%20young%20adolescents.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%281%29%2C%202010.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-29205-8%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-29205-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20mindfulness-based%20intervention%20on%20neurobehavioural%20functioning%20and%20its%20association%20with%20white-matter%20microstructural%20changes%20in%20preterm%20young%20adolescents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Siffredi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Chiara%22%2C%22lastName%22%3A%22Liverani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitri%22%2C%22lastName%22%3A%22Van%20De%20Ville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorena%20G.%20A.%22%2C%22lastName%22%3A%22Freitas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Borradori%20Tolsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20Susan%22%2C%22lastName%22%3A%22H%5Cu00fcppi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Russia%22%2C%22lastName%22%3A%22Ha-Vinh%20Leuchter%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Very%20preterm%20%28VPT%29%20young%20adolescents%20are%20at%20high%20risk%20of%20executive%2C%20behavioural%20and%20socio-emotional%20difficulties.%20Previous%20research%20has%20shown%20significant%20evidence%20of%20the%20benefits%20of%20mindfulness-based%20intervention%20%28MBI%29%20on%20these%20abilities.%20This%20study%20aims%20to%20assess%20the%20association%20between%20the%20effects%20of%20MBI%20on%20neurobehavioral%20functioning%20and%20changes%20in%20white-matter%20microstructure%20in%20VPT%20young%20adolescents%20who%20completed%20an%208-week%20MBI%20program.%20Neurobehavioural%20assessments%20%28i.e.%2C%20neuropsychological%20testing%2C%20parents-%20and%20self-reported%20questionnaires%29%20and%20multi-shell%20diffusion%20MRI%20were%20performed%20before%20and%20after%20MBI%20in%2032%20VPT%20young%20adolescents.%20Combined%20diffusion%20tensor%20imaging%20%28DTI%29%20and%20neurite%20orientation%20dispersion%20and%20density%20imaging%20%28NODDI%29%20measures%20were%20extracted%20on%20well-defined%20white%20matter%20tracts%20%28TractSeg%29.%20A%20multivariate%20data-driven%20approach%20%28partial%20least%20squares%20correlation%29%20was%20used%20to%20explore%20associations%20between%20MBI-related%20changes%20on%20neurobehavioural%20measures%20and%20microstructural%20changes.%20The%20results%20showed%20an%20enhancement%20of%20global%20executive%20functioning%20using%20parent-reported%20questionnaire%20after%20MBI%20that%20was%20associated%20with%20a%20general%20pattern%20of%20increase%20in%20fractional%20anisotropy%20%28FA%29%20and%20decrease%20in%20axonal%20dispersion%20%28ODI%29%20in%20white-matter%20tracts%20involved%20in%20executive%20processes.%20Young%20VPT%20adolescents%20with%20lower%20gestational%20age%20at%20birth%20showed%20the%20greatest%20gain%20in%20white-matter%20microstructural%20changes%20after%20MBI.%22%2C%22date%22%3A%222023-02-03%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-29205-8%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-023-29205-8%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T06%3A47%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22YIZV5ZB2%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Meyer%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMeyer%2C%20N.%20H.%2C%20Gauthier%2C%20B.%2C%20Stampacchia%2C%20S.%2C%20Boscheron%2C%20J.%2C%20Babo-Rebelo%2C%20M.%2C%20Potheegadoo%2C%20J.%2C%20Herbelin%2C%20B.%2C%20Lance%2C%20F.%2C%20Alvarez%2C%20V.%2C%20Franc%2C%20E.%2C%20Esposito%2C%20F.%2C%20Morais%20Lacerda%2C%20M.%2C%20%26amp%3B%20Blanke%2C%20O.%20%282024%29.%20Embodiment%20in%20episodic%20memory%20through%20premotor-hippocampal%20coupling.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%281%29%2C%201111.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06757-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06757-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Embodiment%20in%20episodic%20memory%20through%20premotor-hippocampal%20coupling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathalie%20Heidi%22%2C%22lastName%22%3A%22Meyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Stampacchia%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliette%22%2C%22lastName%22%3A%22Boscheron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariana%22%2C%22lastName%22%3A%22Babo-Rebelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jevita%22%2C%22lastName%22%3A%22Potheegadoo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Herbelin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Lance%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Alvarez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Franc%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabienne%22%2C%22lastName%22%3A%22Esposito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marilia%22%2C%22lastName%22%3A%22Morais%20Lacerda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Blanke%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-09-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-024-06757-7%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-024-06757-7%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-10-01T06%3A32%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22V9KIMZC4%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dhanis%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EDhanis%2C%20H.%2C%20Gninenko%2C%20N.%2C%20Morgenroth%2C%20E.%2C%20Potheegadoo%2C%20J.%2C%20Rognini%2C%20G.%2C%20Faivre%2C%20N.%2C%20Blanke%2C%20O.%2C%20%26amp%3B%20Van%20De%20Ville%2C%20D.%20%282024%29.%20Real-time%20fMRI%20neurofeedback%20modulates%20induced%20hallucinations%20and%20underlying%20brain%20mechanisms.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%281%29%2C%201120.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06842-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-024-06842-x%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Real-time%20fMRI%20neurofeedback%20modulates%20induced%20hallucinations%20and%20underlying%20brain%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herberto%22%2C%22lastName%22%3A%22Dhanis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Gninenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elenor%22%2C%22lastName%22%3A%22Morgenroth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jevita%22%2C%22lastName%22%3A%22Potheegadoo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giulio%22%2C%22lastName%22%3A%22Rognini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Faivre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Blanke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitri%22%2C%22lastName%22%3A%22Van%20De%20Ville%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024-09-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-024-06842-x%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-024-06842-x%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-09-12T14%3A16%3A19Z%22%7D%7D%2C%7B%22key%22%3A%227RAC4ZSF%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mariello%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMariello%2C%20M.%2C%20Rosenthal%2C%20J.%20D.%2C%20Cecchetti%2C%20F.%2C%20Gao%2C%20M.%2C%20Skrivervik%2C%20A.%20K.%2C%20Leterrier%2C%20Y.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282024%29.%20Wireless%2C%20battery-free%2C%20and%20real-time%20monitoring%20of%20water%20permeation%20across%20thin-film%20encapsulation.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E15%3C%5C%2Fi%3E%281%29%2C%207443.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-51247-3%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-51247-3%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Wireless%2C%20battery-free%2C%20and%20real-time%20monitoring%20of%20water%20permeation%20across%20thin-film%20encapsulation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Massimo%22%2C%22lastName%22%3A%22Mariello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20Daniel%22%2C%22lastName%22%3A%22Rosenthal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesco%22%2C%22lastName%22%3A%22Cecchetti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mingxiang%22%2C%22lastName%22%3A%22Gao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%20K.%22%2C%22lastName%22%3A%22Skrivervik%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%22%2C%22lastName%22%3A%22Leterrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Long-term%20bioelectronic%20implants%20require%20stable%2C%20hermetic%20encapsulation.%20Water%20and%20ion%20ingress%20are%20challenging%20to%20quantify%2C%20especially%20in%20miniaturized%20microsystems%20and%20over%20time.%20We%20propose%20a%20wireless%20and%20battery-free%20flexible%20platform%20leveraging%20backscatter%20communication%20and%20magnesium%20%28Mg%29-based%20microsensors.%20Water%20permeation%20through%20the%20encapsulation%20induces%20corrosion%20of%20the%20Mg%20resistive%20sensor%20thereby%20shifting%20the%20oscillation%20frequency%20of%20the%20sensing%20circuit.%20Experimental%20in%20vitro%20and%20in-tissue%20characterization%20provides%20information%20on%20the%20operation%20of%20the%20platform%20and%20demonstrates%20the%20robustness%20and%20accuracy%20of%20this%20promising%20method%2C%20revealing%20its%20significance%20for%20in-situ%20real-time%20monitoring%20of%20implanted%20bioelectronics.%22%2C%22date%22%3A%222024-08-28%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-024-51247-3%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-024-51247-3%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A16%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22FHAJUK5B%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wu%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWu%2C%20K.%2C%20Mariello%2C%20M.%2C%20Leterrier%2C%20Y.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282024%29.%20Optical%20Monitoring%20of%20Water%20Side%20Permeation%20in%20Thin%20Film%20Encapsulation.%20%3Ci%3EAdvanced%20Materials%3C%5C%2Fi%3E%2C%20%3Ci%3E36%3C%5C%2Fi%3E%2824%29%2C%202310201.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadma.202310201%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadma.202310201%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Optical%20Monitoring%20of%20Water%20Side%20Permeation%20in%20Thin%20Film%20Encapsulation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kangling%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Massimo%22%2C%22lastName%22%3A%22Mariello%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%22%2C%22lastName%22%3A%22Leterrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20stability%20of%20long%5Cu2010term%20microfabricated%20implants%20is%20hindered%20by%20the%20presence%20of%20multiple%20water%20diffusion%20paths%20within%20artificially%20patterned%20thin%5Cu2010film%20encapsulations.%20Side%20permeation%2C%20defined%20as%20infiltration%20of%20molecules%20through%20the%20lateral%20surface%20of%20the%20thin%20structure%2C%20becomes%20increasingly%20critical%20with%20the%20trend%20of%20developing%20high%5Cu2010density%20and%20miniaturized%20neural%20electrodes.%20However%2C%20current%20permeability%20measurement%20methods%20do%20not%20account%20for%20side%20permeation%20accurately%20nor%20quantitatively.%20Here%2C%20a%20novel%20optical%2C%20magnesium%20%28Mg%29%5Cu2010based%20method%20is%20proposed%20to%20quantify%20the%20side%20water%20transmission%20rate%20%28SWTR%29%20through%20thin%20film%20encapsulation%20and%20validate%20the%20approach%20using%20micrometric%20polyimide%20%28PI%29%20and%20polyimide%5Cu2010silicon%20carbide%20%28PI%5Cu2010SiC%29%20multilayers.%20Through%20computed%20digital%20grayscale%20images%20collected%20with%20corroding%20Mg%20film%20microcells%20coated%20with%20the%20thin%20encapsulation%2C%20side%20and%20surface%20WTRs%20are%20quantified.%20A%204.5%5Cu2010fold%20ratio%20between%20side%20and%20surface%20permeation%20is%20observed%2C%20highlighting%20the%20crucial%20role%20of%20the%20PI%5Cu2013PI%20interface%20in%20lateral%20diffusion.%20Universal%20guidelines%20for%20the%20design%20of%20flexible%2C%20hermetic%20neural%20interfaces%20are%20proposed.%20Increasing%20encapsulation%27s%20width%20%28interelectrode%20spacing%29%2C%20creating%20stronger%20interfacial%20interactions%2C%20and%20integrating%20high%5Cu2010barrier%20interlayers%20such%20as%20SiC%20significantly%20enhance%20the%20lateral%20hermeticity.%22%2C%22date%22%3A%2206%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fadma.202310201%22%2C%22ISSN%22%3A%220935-9648%2C%201521-4095%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1002%5C%2Fadma.202310201%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A15%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22J5DU4LM2%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fallegger%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFallegger%2C%20F.%2C%20Trouillet%2C%20A.%2C%20Coen%2C%20F.-V.%2C%20Schiavone%2C%20G.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282023%29.%20A%20low-profile%20electromechanical%20packaging%20system%20for%20soft-to-flexible%20bioelectronic%20interfaces.%20%3Ci%3EAPL%20Bioengineering%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%283%29%2C%20036109.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1063%5C%2F5.0152509%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1063%5C%2F5.0152509%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20low-profile%20electromechanical%20packaging%20system%20for%20soft-to-flexible%20bioelectronic%20interfaces%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Trouillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florent-Val%5Cu00e9ry%22%2C%22lastName%22%3A%22Coen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Interfacing%20the%20human%20body%20with%20the%20next%20generation%20of%20electronics%20requires%20technological%20advancement%20in%20designing%20and%20producing%20bioelectronic%20circuits.%20These%20circuits%20must%20integrate%20electrical%20functionality%20while%20simultaneously%20addressing%20limitations%20in%20mechanical%20compliance%20and%20dynamics%2C%20biocompatibility%2C%20and%20consistent%2C%20scalable%20manufacturing.%20The%20combination%20of%20mechanically%20disparate%20materials%20ranging%20from%20elastomers%20to%20inorganic%20crystalline%20semiconductors%20calls%20for%20modular%20designs%20with%20reliable%20and%20scalable%20electromechanical%20connectors.%20Here%2C%20we%20report%20on%20a%20novel%20interconnection%20solution%20for%20soft-to-flexible%20bioelectronic%20interfaces%20using%20a%20patterned%20and%20machined%20flexible%20printed%20circuit%20board%2C%20which%20we%20term%20FlexComb%2C%20interfaced%20with%20soft%20transducing%20systems.%20Using%20a%20simple%20assembly%20process%2C%20arrays%20of%20protruding%20%5Cu201cfingers%5Cu201d%20bearing%20individual%20electrical%20terminals%20are%20laser-machined%20on%20a%20standard%20flexible%20printed%20circuit%20board%20to%20create%20a%20comb-like%20structure%2C%20namely%2C%20the%20FlexComb.%20A%20matching%20pattern%20is%20also%20machined%20in%20the%20soft%20system%20to%20host%20and%20interlock%20electromechanically%20the%20FlexComb%20connections%20via%20a%20soft%20electrically%20conducting%20composite.%20We%20examine%20the%20electrical%20and%20electromechanical%20properties%20of%20the%20interconnection%20and%20demonstrate%20the%20versatility%20and%20scalability%20of%20the%20method%20through%20various%20customized%20submillimetric%20designs.%20In%20a%20pilot%20in%20vivo%20study%2C%20we%20validate%20the%20stability%20and%20compatibility%20of%20the%20FlexComb%20technology%20in%20a%20subdural%20electrocorticography%20system%20implanted%20for%206%5Cu2009months%20on%20the%20auditory%20cortex%20of%20a%20minipig.%20The%20FlexComb%20provides%20a%20reliable%20and%20simple%20technique%20to%20bond%20and%20connect%20soft%20transducing%20systems%20with%20flexible%20or%20rigid%20electronic%20boards%2C%20which%20should%20find%20many%20implementations%20in%20soft%20robotics%20and%20wearable%20and%20implantable%20bioelectronics.%22%2C%22date%22%3A%222023-09-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1063%5C%2F5.0152509%22%2C%22ISSN%22%3A%222473-2877%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.aip.org%5C%2Fapb%5C%2Farticle%5C%2F7%5C%2F3%5C%2F036109%5C%2F2907369%5C%2FA-low-profile-electromechanical-packaging-system%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A14%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22J73ZDF8B%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Song%20et%20al.%22%2C%22parsedDate%22%3A%222023-05-31%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESong%2C%20S.%2C%20Fallegger%2C%20F.%2C%20Trouillet%2C%20A.%2C%20Kim%2C%20K.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282023%29.%20Deployment%20of%20an%20electrocorticography%20system%20with%20a%20soft%20robotic%20actuator.%20%3Ci%3EScience%20Robotics%3C%5C%2Fi%3E%2C%20%3Ci%3E8%3C%5C%2Fi%3E%2878%29%2C%20eadd1002.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscirobotics.add1002%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscirobotics.add1002%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deployment%20of%20an%20electrocorticography%20system%20with%20a%20soft%20robotic%20actuator%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sukho%22%2C%22lastName%22%3A%22Song%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Trouillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Electrocorticography%20%28ECoG%29%20is%20a%20minimally%20invasive%20approach%20frequently%20used%20clinically%20to%20map%20epileptogenic%20regions%20of%20the%20brain%20and%20facilitate%20lesion%20resection%20surgery%20and%20increasingly%20explored%20in%20brain-machine%20interface%20applications.%20Current%20devices%20display%20limitations%20that%20require%20trade-offs%20among%20cortical%20surface%20coverage%2C%20spatial%20electrode%20resolution%2C%20aesthetic%2C%20and%20risk%20consequences%20and%20often%20limit%20the%20use%20of%20the%20mapping%20technology%20to%20the%20operating%20room.%20In%20this%20work%2C%20we%20report%20on%20a%20scalable%20technique%20for%20the%20fabrication%20of%20large-area%20soft%20robotic%20electrode%20arrays%20and%20their%20deployment%20on%20the%20cortex%20through%20a%20square-centimeter%20burr%20hole%20using%20a%20pressure-driven%20actuation%20mechanism%20called%20eversion.%20The%20deployable%20system%20consists%20of%20up%20to%20six%20prefolded%20soft%20legs%2C%20and%20it%20is%20placed%20subdurally%20on%20the%20cortex%20using%20an%20aqueous%20pressurized%20solution%20and%20secured%20to%20the%20pedestal%20on%20the%20rim%20of%20the%20small%20craniotomy.%20Each%20leg%20contains%20soft%2C%20microfabricated%20electrodes%20and%20strain%20sensors%20for%20real-time%20deployment%20monitoring.%20In%20a%20proof-of-concept%20acute%20surgery%2C%20a%20soft%20robotic%20electrode%20array%20was%20successfully%20deployed%20on%20the%20cortex%20of%20a%20minipig%20to%20record%20sensory%20cortical%20activity.%20This%20soft%20robotic%20neurotechnology%20opens%20promising%20avenues%20for%20minimally%20invasive%20cortical%20surgery%20and%20applications%20related%20to%20neurological%20disorders%20such%20as%20motor%20and%20sensory%20deficits.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Soft%20robotic%20actuation%20with%20bioelectronics%20were%20combined%20to%20develop%20minimally%20invasive%2C%20deployable%20cortical%20electrode%20arrays.%22%2C%22date%22%3A%222023-05-31%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscirobotics.add1002%22%2C%22ISSN%22%3A%222470-9476%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fscirobotics.add1002%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A14%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22QDLI4S5N%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fallegger%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-31%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFallegger%2C%20F.%2C%20Trouillet%2C%20A.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282023%29.%20Subdural%20Soft%20Electrocorticography%20%28ECoG%29%20Array%20Implantation%20and%20Long-Term%20Cortical%20Recording%20in%20Minipigs.%20%3Ci%3EJournal%20of%20Visualized%20Experiments%3C%5C%2Fi%3E%2C%20%3Ci%3E193%3C%5C%2Fi%3E%2C%2064997.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3791%5C%2F64997%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3791%5C%2F64997%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Subdural%20Soft%20Electrocorticography%20%28ECoG%29%20Array%20Implantation%20and%20Long-Term%20Cortical%20Recording%20in%20Minipigs%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alix%22%2C%22lastName%22%3A%22Trouillet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023-3-31%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3791%5C%2F64997%22%2C%22ISSN%22%3A%221940-087X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fapp.jove.com%5C%2Ft%5C%2F64997%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A13%3A59Z%22%7D%7D%2C%7B%22key%22%3A%229LF3MZMU%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Borda%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBorda%2C%20E.%2C%20Medagoda%2C%20D.%20I.%2C%20Airaghi%20Leccardi%2C%20M.%20J.%20I.%2C%20Zollinger%2C%20E.%20G.%2C%20%26amp%3B%20Ghezzi%2C%20D.%20%282023%29.%20Conformable%20neural%20interface%20based%20on%20off-stoichiometry%20thiol-ene-epoxy%20thermosets.%20%3Ci%3EBiomaterials%3C%5C%2Fi%3E%2C%20%3Ci%3E293%3C%5C%2Fi%3E%2C%20121979.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2022.121979%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2022.121979%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Conformable%20neural%20interface%20based%20on%20off-stoichiometry%20thiol-ene-epoxy%20thermosets%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleonora%22%2C%22lastName%22%3A%22Borda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Danashi%20Imani%22%2C%22lastName%22%3A%22Medagoda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%20Jole%20Ildelfonsa%22%2C%22lastName%22%3A%22Airaghi%20Leccardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%20Genevi%5Cu00e8ve%22%2C%22lastName%22%3A%22Zollinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diego%22%2C%22lastName%22%3A%22Ghezzi%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2202%5C%2F2023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.biomaterials.2022.121979%22%2C%22ISSN%22%3A%2201429612%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0142961222006196%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A13%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22V8257WXD%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nayir%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENayir%2C%20S.%2C%20Lacour%2C%20S.%20P.%2C%20%26amp%3B%20Kucera%2C%20J.%20P.%20%282022%29.%20Active%20force%20generation%20contributes%20to%20the%20complexity%20of%20spontaneous%20activity%20and%20to%20the%20response%20to%20stretch%20of%20murine%20cardiomyocyte%20cultures.%20%3Ci%3EThe%20Journal%20of%20Physiology%3C%5C%2Fi%3E%2C%20%3Ci%3E600%3C%5C%2Fi%3E%2814%29%2C%203287%26%23x2013%3B3312.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1113%5C%2FJP283083%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1113%5C%2FJP283083%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Active%20force%20generation%20contributes%20to%20the%20complexity%20of%20spontaneous%20activity%20and%20to%20the%20response%20to%20stretch%20of%20murine%20cardiomyocyte%20cultures%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyma%22%2C%22lastName%22%3A%22Nayir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20P.%22%2C%22lastName%22%3A%22Kucera%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Cardiomyocyte%20cultures%20exhibit%20spontaneous%20electrical%20and%20contractile%20activity%2C%20as%20in%20a%20natural%20cardiac%20pacemaker.%20In%20such%20preparations%2C%20beat%20rate%20variability%20exhibits%20features%20similar%20to%20those%20of%20heart%20rate%20variability%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20Mechanical%20deformations%20and%20forces%20feed%20back%20on%20the%20electrical%20properties%20of%20cardiomyocytes%2C%20but%20it%20is%20not%20fully%20elucidated%20how%20this%20mechano%5Cu2010electrical%20interplay%20affects%20beating%20variability%20in%20such%20preparations.%20Using%20stretchable%20microelectrode%20arrays%2C%20we%20assessed%20the%20effects%20of%20the%20myosin%20inhibitor%20blebbistatin%20and%20the%20non%5Cu2010selective%20stretch%5Cu2010activated%20channel%20blocker%20streptomycin%20on%20beating%20variability%20and%20on%20the%20response%20of%20neonatal%20or%20fetal%20murine%20ventricular%20cell%20cultures%20against%20deformation.%20Spontaneous%20electrical%20activity%20was%20recorded%20without%20stretch%20and%20upon%20predefined%20deformation%20protocols%20%285%25%20uniaxial%20and%202%25%20equibiaxial%20strain%2C%20applied%20repeatedly%20for%201%5Cu00a0min%20every%203%5Cu00a0min%29.%20Without%20stretch%2C%20spontaneous%20activity%20originated%20from%20the%20edge%20of%20the%20preparations%2C%20and%20its%20site%20of%20origin%20switched%20frequently%20in%20a%20complex%20manner%20across%20the%20cultures.%20Blebbistatin%20did%20not%20change%20mean%20beat%20rate%2C%20but%20it%20decreased%20the%20spatial%20complexity%20of%20spontaneous%20activity.%20In%20contrast%2C%20streptomycin%20did%20not%20exert%20any%20manifest%20effects.%20During%20the%20deformation%20protocols%2C%20beat%20rate%20increased%20transiently%20upon%20stretch%20but%2C%20paradoxically%2C%20also%20upon%20release.%20Blebbistatin%20attenuated%20the%20response%20to%20stretch%2C%20whereas%20this%20response%20was%20not%20affected%20by%20streptomycin.%20Therefore%2C%20our%20data%20support%20the%20notion%20that%20in%20a%20spontaneously%20firing%20network%20of%20cardiomyocytes%2C%20active%20force%20generation%2C%20rather%20than%20stretch%5Cu2010activated%20channels%2C%20is%20involved%20mechanistically%20in%20the%20complexity%20of%20the%20spatiotemporal%20patterns%20of%20spontaneous%20activity%20and%20in%20the%20stretch%5Cu2010induced%20acceleration%20of%20beating.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20image%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Key%20points%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Monolayer%20cultures%20of%20cardiac%20cells%20exhibit%20spontaneous%20electrical%20and%20contractile%20activity%2C%20as%20in%20a%20natural%20cardiac%20pacemaker.%20Beating%20variability%20in%20these%20preparations%20recapitulates%20the%20power%5Cu2010law%20behaviour%20of%20heart%20rate%20variability%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20However%2C%20the%20effects%20of%20mechano%5Cu2010electrical%20feedback%20on%20beating%20variability%20are%20not%20yet%20fully%20understood.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Using%20stretchable%20microelectrode%20arrays%2C%20we%20examined%20the%20effects%20of%20the%20contraction%20uncoupler%20blebbistatin%20and%20the%20non%5Cu2010specific%20stretch%5Cu2010activated%20channel%20blocker%20streptomycin%20on%20beating%20variability%20and%20on%20stretch%5Cu2010induced%20changes%20of%20beat%20rate.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Without%20stretch%2C%20blebbistatin%20decreased%20the%20spatial%20complexity%20of%20beating%20variability%2C%20whereas%20streptomycin%20had%20no%20effects.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Both%20stretch%20and%20release%20increased%20beat%20rate%20transiently%3B%20blebbistatin%20attenuated%20the%20increase%20of%20beat%20rate%20upon%20stretch%2C%20whereas%20streptomycin%20had%20no%20effects.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Active%20force%20generation%20contributes%20to%20the%20complexity%20of%20spatiotemporal%20patterns%20of%20beating%20variability%20and%20to%20the%20increase%20of%20beat%20rate%20upon%20mechanical%20deformation.%20Our%20study%20contributes%20to%20the%20understanding%20of%20how%20mechano%5Cu2010electrical%20feedback%20influences%20heart%20rate%20variability.%22%2C%22date%22%3A%2207%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1113%5C%2FJP283083%22%2C%22ISSN%22%3A%220022-3751%2C%201469-7793%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fphysoc.onlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1113%5C%2FJP283083%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A13%3A03Z%22%7D%7D%2C%7B%22key%22%3A%226BACKNXJ%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kim%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKim%2C%20K.%2C%20Van%20Gompel%2C%20M.%2C%20Wu%2C%20K.%2C%20Schiavone%2C%20G.%2C%20Carron%2C%20J.%2C%20Bourgeois%2C%20F.%2C%20Lacour%2C%20S.%20P.%2C%20%26amp%3B%20Leterrier%2C%20Y.%20%282021%29.%20Extended%20Barrier%20Lifetime%20of%20Partially%20Cracked%20Organic%5C%2FInorganic%20Multilayers%20for%20Compliant%20Implantable%20Electronics.%20%3Ci%3ESmall%3C%5C%2Fi%3E%2C%20%3Ci%3E17%3C%5C%2Fi%3E%2840%29%2C%202103039.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsmll.202103039%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fsmll.202103039%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extended%20Barrier%20Lifetime%20of%20Partially%20Cracked%20Organic%5C%2FInorganic%20Multilayers%20for%20Compliant%20Implantable%20Electronics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Van%20Gompel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kangling%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Carron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Bourgeois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%22%2C%22lastName%22%3A%22Leterrier%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Flexible%20and%20soft%20bioelectronics%20display%20conflicting%20demands%20on%20miniaturization%2C%20compliance%2C%20and%20reliability.%20Here%2C%20the%20authors%20investigate%20the%20design%20and%20performance%20of%20thin%20encapsulation%20multilayers%20against%20hermeticity%20and%20mechanical%20integrity.%20Partially%20cracked%20organic%5C%2Finorganic%20multilayer%20coatings%20are%20demonstrated%20to%20display%20surprisingly%20year%5Cu2010long%20hermetic%20lifetime%20under%20demanding%20mechanical%20and%20environmental%20loading.%20The%20thin%20hermetic%20encapsulation%20is%20grown%20in%20a%20single%20process%20chamber%20as%20a%20continuous%20multilayer%20with%20dyads%20of%20atomic%20layer%20deposited%20%28ALD%29%20Al%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20O%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%203%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2010TiO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%20chemical%20vapor%20deposited%20Parylene%20C%20films%20with%20strong%20interlayer%20adhesion.%20Upon%20tensile%20loading%2C%20tortuous%20diffusion%20pathways%20defined%20along%20channel%20cracks%20in%20the%20ALD%20oxide%20films%20and%20through%20tough%20Parylene%20films%20efficiently%20postpone%20the%20hermeticity%20failure%20of%20the%20partially%20cracked%20coating.%20The%20authors%20assessed%20the%20coating%20performance%20against%20prolonged%20exposure%20to%20biomimetic%20physiological%20conditions%20using%20coated%20magnesium%20films%2C%20platinum%20interdigitated%20electrodes%2C%20and%20optoelectronic%20devices%20prepared%20on%20stretchable%20substrates.%20Designed%20extension%20of%20the%20lifetime%20preventing%20direct%20failures%20reduces%20from%20over%205%20years%20yet%20tolerates%20the%20lifetime%20of%203%20years%20even%20with%20the%20presence%20of%20critical%20damage%2C%20while%20others%20will%20directly%20fail%20less%20than%20two%20months%20at%2037%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00b0%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20C.%20This%20strategy%20should%20accelerate%20progress%20on%20thin%20hermetic%20packaging%20for%20miniaturized%20and%20compliant%20implantable%20electronics.%22%2C%22date%22%3A%2210%5C%2F2021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fsmll.202103039%22%2C%22ISSN%22%3A%221613-6810%2C%201613-6829%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1002%5C%2Fsmll.202103039%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A12%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22H8GZK4DU%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schiavone%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESchiavone%2C%20G.%2C%20Vachicouras%2C%20N.%2C%20Vyza%2C%20Y.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282021%29.%20Dimensional%20scaling%20of%20thin-film%20stimulation%20electrode%20systems%20in%20translational%20research.%20%3Ci%3EJournal%20of%20Neural%20Engineering%3C%5C%2Fi%3E%2C%20%3Ci%3E18%3C%5C%2Fi%3E%284%29%2C%20046054.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1741-2552%5C%2Fabf607%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1741-2552%5C%2Fabf607%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Dimensional%20scaling%20of%20thin-film%20stimulation%20electrode%20systems%20in%20translational%20research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vachicouras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yashwanth%22%2C%22lastName%22%3A%22Vyza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objective.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Electrical%20stimulation%20of%20biological%20tissue%20is%20an%20established%20technique%20in%20research%20and%20clinical%20practice%20that%20uses%20implanted%20electrodes%20to%20deliver%20electrical%20pulses%20for%20a%20variety%20of%20therapies.%20Significant%20research%20currently%20explores%20new%20electrode%20system%20technologies%20and%20stimulation%20protocols%20in%20preclinical%20models%2C%20aiming%20at%20both%20improving%20the%20electrode%20performance%20and%20confirming%20therapeutic%20efficacy.%20Assessing%20the%20scalability%20of%20newly%20proposed%20electrode%20technology%20and%20their%20use%20for%20tissue%20stimulation%20remains%2C%20however%2C%20an%20open%20question.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Approach.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20propose%20a%20simplified%20electrical%20model%20that%20formalizes%20the%20dimensional%20scaling%20of%20stimulation%20electrode%20systems.%20We%20use%20established%20equations%20describing%20the%20electrode%20impedance%2C%20and%20apply%20them%20to%20the%20case%20of%20stimulation%20electrodes%20driven%20by%20a%20voltage-capped%20pulse%20generator.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Main%20results.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20find%20a%20hard%2C%20intrinsic%20upward%20scalability%20limit%20to%20the%20electrode%20radius%20that%20largely%20depends%20on%20the%20conductor%20technology.%20We%20finally%20provide%20a%20simple%20analytical%20formula%20predicting%20the%20maximum%20size%20of%20a%20stimulation%20electrode%20as%20a%20function%20of%20the%20stimulation%20parameters%20and%20conductor%20resistance.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Significance.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20results%20highlight%20the%20importance%20of%20careful%20geometrical%20and%20electrical%20designs%20of%20electrode%20systems%20based%20on%20novel%20thin-film%20technologies%20and%20that%20become%20particularly%20relevant%20for%20their%20translational%20implementation%20with%20electrode%20geometries%20approaching%20clinical%20human%20size%20electrodes%20and%20interfacing%20with%20voltage-capped%20neurostimulation%20systems.%22%2C%22date%22%3A%222021-08-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1088%5C%2F1741-2552%5C%2Fabf607%22%2C%22ISSN%22%3A%221741-2560%2C%201741-2552%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fiopscience.iop.org%5C%2Farticle%5C%2F10.1088%5C%2F1741-2552%5C%2Fabf607%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-11T15%3A12%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22UQWKX4RY%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A14964934%2C%22username%22%3A%22olivier.reynaud%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Folivier.reynaud%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Moon%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMoon%2C%20H.-J.%2C%20Gauthier%2C%20B.%2C%20Park%2C%20H.-D.%2C%20Faivre%2C%20N.%2C%20%26amp%3B%20Blanke%2C%20O.%20%282022%29.%20Sense%20of%20self%20impacts%20spatial%20navigation%20and%20hexadirectional%20coding%20in%20human%20entorhinal%20cortex.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E5%3C%5C%2Fi%3E%281%29%2C%20406.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-022-03361-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-022-03361-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Sense%20of%20self%20impacts%20spatial%20navigation%20and%20hexadirectional%20coding%20in%20human%20entorhinal%20cortex%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hyuk-June%22%2C%22lastName%22%3A%22Moon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baptiste%22%2C%22lastName%22%3A%22Gauthier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hyeong-Dong%22%2C%22lastName%22%3A%22Park%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Faivre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Blanke%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Grid%20cells%20in%20entorhinal%20cortex%20%28EC%29%20encode%20an%20individual%5Cu2019s%20location%20in%20space%20and%20rely%20on%20environmental%20cues%20and%20self-motion%20cues%20derived%20from%20the%20individual%5Cu2019s%20body.%20Body-derived%20signals%20are%20also%20primary%20signals%20for%20the%20sense%20of%20self%20and%20based%20on%20integrated%20sensorimotor%20signals%20%28proprioceptive%2C%20tactile%2C%20visual%2C%20motor%29%20that%20have%20been%20shown%20to%20enhance%20self-centered%20processing.%20However%2C%20it%20is%20currently%20unknown%20whether%20such%20sensorimotor%20signals%20that%20modulate%20self-centered%20processing%20impact%20grid%20cells%20and%20spatial%20navigation.%20Integrating%20the%20online%20manipulation%20of%20bodily%20signals%2C%20to%20modulate%20self-centered%20processing%2C%20with%20a%20spatial%20navigation%20task%20and%20an%20fMRI%20measure%20to%20detect%20grid%20cell-like%20representation%20%28GCLR%29%20in%20humans%2C%20we%20report%20improved%20performance%20in%20spatial%20navigation%20and%20decreased%20GCLR%20in%20EC.%20This%20decrease%20in%20entorhinal%20GCLR%20was%20associated%20with%20an%20increase%20in%20retrosplenial%20cortex%20activity%2C%20which%20was%20correlated%20with%20participants%5Cu2019%20navigation%20performance.%20These%20data%20link%20self-centered%20processes%20during%20spatial%20navigation%20to%20entorhinal%20and%20retrosplenial%20activity%20and%20highlight%20the%20role%20of%20different%20bodily%20factors%20at%20play%20when%20navigating%20in%20VR.%22%2C%22date%22%3A%222022-05-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-022-03361-5%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-022-03361-5%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%222E6FW5HR%22%5D%2C%22dateModified%22%3A%222024-09-11T07%3A24%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22YDKUZDJ8%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A14964934%2C%22username%22%3A%22olivier.reynaud%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Folivier.reynaud%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Li%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-26%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELi%2C%20A.%2C%20Feitelberg%2C%20J.%2C%20Saini%2C%20A.%20P.%2C%20H%26%23xF6%3Bchenberger%2C%20R.%2C%20%26amp%3B%20Scheltienne%2C%20M.%20%282022%29.%20MNE-ICALabel%3A%20Automatically%20annotating%20ICA%20components%20with%20ICLabel%20in%20Python.%20%3Ci%3EJournal%20of%20Open%20Source%20Software%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%2876%29%2C%204484.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21105%5C%2Fjoss.04484%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21105%5C%2Fjoss.04484%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MNE-ICALabel%3A%20Automatically%20annotating%20ICA%20components%20with%20ICLabel%20in%20Python%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adam%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacob%22%2C%22lastName%22%3A%22Feitelberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anand%20Prakash%22%2C%22lastName%22%3A%22Saini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22H%5Cu00f6chenberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathieu%22%2C%22lastName%22%3A%22Scheltienne%22%7D%5D%2C%22abstractNote%22%3A%22Li%20et%20al.%2C%20%282022%29.%20MNE-ICALabel%3A%20Automatically%20annotating%20ICA%20components%20with%20ICLabel%20in%20Python.%20Journal%20of%20Open%20Source%20Software%2C%207%2876%29%2C%204484%2C%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21105%5C%2Fjoss.04484%22%2C%22date%22%3A%222022%5C%2F08%5C%2F26%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.21105%5C%2Fjoss.04484%22%2C%22ISSN%22%3A%222475-9066%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjoss.theoj.org%5C%2Fpapers%5C%2F10.21105%5C%2Fjoss.04484%22%2C%22collections%22%3A%5B%22QZJCI396%22%2C%22QWCYR4J9%22%5D%2C%22dateModified%22%3A%222024-09-09T13%3A15%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22GYZ6V2D8%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sanches%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESanches%2C%20E.%2C%20Ho%2C%20D.%2C%20Van%20De%20Looij%2C%20Y.%2C%20Aebi%20Toulotte%2C%20A.%2C%20Baud%2C%20L.%2C%20Bouteldja%2C%20F.%2C%20Barraud%2C%20Q.%2C%20Araneda%2C%20R.%2C%20Bleyenheuft%2C%20Y.%2C%20Brochard%2C%20S.%2C%20Kathe%2C%20C.%2C%20Courtine%2C%20G.%2C%20%26amp%3B%20Sizonenko%2C%20S.%20%282024%29.%20Early%20intensive%20rehabilitation%20reverses%20locomotor%20disruption%2C%20decrease%20brain%20inflammation%20and%20induces%20neuroplasticity%20following%20experimental%20Cerebral%20Palsy.%20%3Ci%3EBrain%2C%20Behavior%2C%20and%20Immunity%3C%5C%2Fi%3E%2C%20%3Ci%3E121%3C%5C%2Fi%3E%2C%20303%26%23x2013%3B316.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bbi.2024.08.005%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.bbi.2024.08.005%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Early%20intensive%20rehabilitation%20reverses%20locomotor%20disruption%2C%20decrease%20brain%20inflammation%20and%20induces%20neuroplasticity%20following%20experimental%20Cerebral%20Palsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%22%2C%22lastName%22%3A%22Sanches%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dini%22%2C%22lastName%22%3A%22Ho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yohan%22%2C%22lastName%22%3A%22Van%20De%20Looij%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Audrey%22%2C%22lastName%22%3A%22Aebi%20Toulotte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Farha%22%2C%22lastName%22%3A%22Bouteldja%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodrigo%22%2C%22lastName%22%3A%22Araneda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Bleyenheuft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Brochard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Sizonenko%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2210%5C%2F2024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.bbi.2024.08.005%22%2C%22ISSN%22%3A%2208891591%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0889159124005270%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A35%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22NNBC5US7%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ho%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHo%2C%20D.%2C%20Sanches%2C%20E.%20F.%2C%20%26amp%3B%20Sizonenko%2C%20S.%20V.%20%282022%29.%20Early%20neurodevelopmental%20reflex%20impairments%20in%20a%20rodent%20model%20of%20cerebral%20palsy.%20%3Ci%3EInternational%20Journal%20of%20Developmental%20Neuroscience%3C%5C%2Fi%3E%2C%20%3Ci%3E82%3C%5C%2Fi%3E%288%29%2C%20814%26%23x2013%3B822.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjdn.10235%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjdn.10235%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Early%20neurodevelopmental%20reflex%20impairments%20in%20a%20rodent%20model%20of%20cerebral%20palsy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dini%22%2C%22lastName%22%3A%22Ho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%20F.%22%2C%22lastName%22%3A%22Sanches%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%20V.%22%2C%22lastName%22%3A%22Sizonenko%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Cerebral%20palsy%20%28CP%29%20causes%20sensorimotor%20disabilities%20due%20to%20injury%20to%20the%20developing%20brain.%20Experimental%20models%20do%20not%20always%20induce%20the%20CP%20phenotype%20completely.%20Early%20neurological%20assessment%20predicts%20future%20impairments%20and%20is%20valuable%20during%20development.%20Using%20a%20rodent%20model%20characterized%20by%20brain%20injury%20caused%20by%20maternal%20inflammation%20and%20perinatal%20anoxia%2C%20and%20sensorimotor%20restriction%20%28experimental%20cerebral%20palsy%20%5BECP%5D%29%2C%20we%20describe%20early%20neurodevelopmental%20delays%20by%20assessing%20reflexes%20in%20a%20stage%20corresponding%20to%20the%20brain%20development%20of%20term%20infants%20%28Postnatal%20Day%20%5BP%5D%208%20in%20rats%29.%20Pregnant%20Wistar%20rats%20were%20injected%20with%20lipopolysaccharide%20%28LPS%3B%20200%5Cu2009%5Cu03bcg%5C%2Fkg%29%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20096%29%20or%20saline%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20094%29%20on%20Embryonic%20Days%2018%5C%2F19.%20Following%20delivery%2C%2087%20male%20and%20female%20pups%20were%20used.%20At%20P0%2C%20injured%20animals%20were%20exposed%20to%20anoxia%20for%2020%5Cu2032.%20From%20P2%20to%20P21%2C%20ECP%20rats%20were%20subjected%20to%20hindlimb%20movement%20restriction%20for%2016%5Cu2009h%5C%2Fday.%20ECP%20group%20had%20impaired%20righting%20reflex%20and%20negative%20geotaxis%20and%2C%20interestingly%2C%20performed%20home%20bedding%20test%20better%20than%20controls.%20From%20P7%2C%20ECP%20animals%20showed%20decreased%20body%20weight%20compared%20with%20controls.%20Overall%2C%20data%20provide%20evidence%20showing%20that%20this%20CP%20model%20based%20on%20the%20association%20of%20brain%20damage%20followed%20by%20sensorimotor%20restriction%20mimics%20CP%20delays%20and%20highlights%20the%20valuable%20information%20given%20by%20early%20neurological%20assessment%20during%20the%20establishment%20of%20the%20CP%20phenotype.%22%2C%22date%22%3A%2212%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fjdn.10235%22%2C%22ISSN%22%3A%220736-5748%2C%201873-474X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1002%5C%2Fjdn.10235%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A35%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22K4VELHZQ%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22D%27Amico%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ED%26%23x2019%3BAmico%2C%20D.%2C%20Olmer%2C%20M.%2C%20Fouassier%2C%20A.%20M.%2C%20Vald%26%23xE9%3Bs%2C%20P.%2C%20Andreux%2C%20P.%20A.%2C%20Rinsch%2C%20C.%2C%20%26amp%3B%20Lotz%2C%20M.%20%282022%29.%20Urolithin%20A%20improves%20mitochondrial%20health%2C%20reduces%20cartilage%20degeneration%2C%20and%20alleviates%20pain%20in%20osteoarthritis.%20%3Ci%3EAging%20Cell%3C%5C%2Fi%3E%2C%20%3Ci%3E21%3C%5C%2Fi%3E%288%29%2C%20e13662.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Facel.13662%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Facel.13662%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Urolithin%20A%20improves%20mitochondrial%20health%2C%20reduces%20cartilage%20degeneration%2C%20and%20alleviates%20pain%20in%20osteoarthritis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Davide%22%2C%22lastName%22%3A%22D%27Amico%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Merissa%22%2C%22lastName%22%3A%22Olmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9ane%20M.%22%2C%22lastName%22%3A%22Fouassier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pamela%22%2C%22lastName%22%3A%22Vald%5Cu00e9s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%5Cu00e9n%5Cu00e9lope%20A.%22%2C%22lastName%22%3A%22Andreux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Rinsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Lotz%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Osteoarthritis%20%28OA%29%20is%20the%20most%20common%20age%5Cu2010related%20joint%20disorder%20with%20no%20effective%20therapy.%20According%20to%20the%20World%20Health%20Organization%2C%20OA%20affects%20over%20500%20million%20people%20and%20is%20characterized%20by%20degradation%20of%20cartilage%20and%20other%20joint%20tissues%2C%20severe%20pain%2C%20and%20impaired%20mobility.%20Mitochondrial%20dysfunction%20contributes%20to%20OA%20pathology.%20However%2C%20interventions%20to%20rescue%20mitochondrial%20defects%20in%20human%20OA%20are%20not%20available.%20Urolithin%20A%20%28Mitopure%29%20is%20a%20natural%20postbiotic%20compound%20that%20promotes%20mitophagy%20and%20mitochondrial%20function%20and%20beneficially%20impacts%20muscle%20health%20in%20preclinical%20models%20of%20aging%20and%20in%20elderly%20and%20middle%5Cu2010aged%20humans.%20Here%2C%20we%20showed%20that%20Urolithin%20A%20improved%20mitophagy%20and%20mitochondrial%20respiration%20in%20primary%20chondrocytes%20from%20joints%20of%20both%20healthy%20donors%20and%20OA%20patients.%20Furthermore%2C%20Urolithin%20A%20reduced%20disease%20progression%20in%20a%20mouse%20model%20of%20OA%2C%20decreasing%20cartilage%20degeneration%2C%20synovial%20inflammation%2C%20and%20pain.%20These%20improvements%20were%20associated%20with%20increased%20mitophagy%20and%20mitochondrial%20content%2C%20in%20joints%20of%20OA%20mice.%20These%20findings%20indicate%20that%20UA%20promotes%20joint%20mitochondrial%20health%2C%20alleviates%20OA%20pathology%2C%20and%20supports%20Urolithin%20A%27s%20potential%20to%20improve%20mobility%20with%20beneficial%20effects%20on%20structural%20damage%20in%20joints.%22%2C%22date%22%3A%2208%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1111%5C%2Facel.13662%22%2C%22ISSN%22%3A%221474-9718%2C%201474-9726%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1111%5C%2Facel.13662%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A35%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22P3CN3RIB%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Singh%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESingh%2C%20A.%2C%20D%26%23x2019%3BAmico%2C%20D.%2C%20Andreux%2C%20P.%20A.%2C%20Fouassier%2C%20A.%20M.%2C%20Blanco-Bose%2C%20W.%2C%20Evans%2C%20M.%2C%20Aebischer%2C%20P.%2C%20Auwerx%2C%20J.%2C%20%26amp%3B%20Rinsch%2C%20C.%20%282022%29.%20Urolithin%20A%20improves%20muscle%20strength%2C%20exercise%20performance%2C%20and%20biomarkers%20of%20mitochondrial%20health%20in%20a%20randomized%20trial%20in%20middle-aged%20adults.%20%3Ci%3ECell%20Reports%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E3%3C%5C%2Fi%3E%285%29%2C%20100633.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xcrm.2022.100633%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.xcrm.2022.100633%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Urolithin%20A%20improves%20muscle%20strength%2C%20exercise%20performance%2C%20and%20biomarkers%20of%20mitochondrial%20health%20in%20a%20randomized%20trial%20in%20middle-aged%20adults%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anurag%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Davide%22%2C%22lastName%22%3A%22D%5Cu2019Amico%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P%5Cu00e9n%5Cu00e9lope%20A.%22%2C%22lastName%22%3A%22Andreux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9ane%20M.%22%2C%22lastName%22%3A%22Fouassier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%22%2C%22lastName%22%3A%22Blanco-Bose%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mal%22%2C%22lastName%22%3A%22Evans%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Aebischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johan%22%2C%22lastName%22%3A%22Auwerx%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Rinsch%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2205%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.xcrm.2022.100633%22%2C%22ISSN%22%3A%2226663791%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2666379122001586%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A34%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22APIJ9UF9%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22D%5Cu2019Amico%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ED%26%23x2019%3BAmico%2C%20D.%2C%20Fouassier%2C%20A.%2C%20Faitg%2C%20J.%2C%20Hennighausen%2C%20N.%2C%20Brandt%2C%20M.%2C%20Konstantopoulos%2C%20D.%2C%20Rinsch%2C%20C.%2C%20%26amp%3B%20Singh%2C%20A.%20%282023%29.%20%3Ci%3ETopical%20application%20of%20Urolithin%20A%20slows%20intrinsic%20skin%20aging%20and%20protects%20from%20UVB-mediated%20photodamage%3A%20Findings%20from%20Randomized%20Clinical%20Trials%3C%5C%2Fi%3E.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.06.16.23291378%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.06.16.23291378%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22Topical%20application%20of%20Urolithin%20A%20slows%20intrinsic%20skin%20aging%20and%20protects%20from%20UVB-mediated%20photodamage%3A%20Findings%20from%20Randomized%20Clinical%20Trials%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22D%5Cu2019Amico%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Am%22%2C%22lastName%22%3A%22Fouassier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%22%2C%22lastName%22%3A%22Faitg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N%22%2C%22lastName%22%3A%22Hennighausen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%22%2C%22lastName%22%3A%22Brandt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D%22%2C%22lastName%22%3A%22Konstantopoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Rinsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A%22%2C%22lastName%22%3A%22Singh%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Urolithin%20A%20is%20a%20gut%20microbiome%20derived%20postbiotic%20that%20has%20been%20shown%20to%20stimulate%20mitophagy%2C%20and%20improve%20muscle%20and%20mitochondrial%20health%20when%20administered%20orally%20to%20humans.%20In%20three%20separate%20randomized%20trials%2C%20we%20have%20now%20investigated%20the%20effect%20of%20topical%20administration%20of%20Urolithin%20A%20on%20skin%20aging%20features%20and%20on%20UVB-mediated%20photodamaged%20skin.%20Post-menopausal%20women%20with%20evidence%20of%20skin%20aging%20such%20as%20%3E%20Grade%203%20wrinkle%20formation%20were%20included%20in%20a%20split-face%5C%2Farm%20study%20design%20in%20the%20first%20trial%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%201%3B%20n%3D48%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%29%2C%20followed%20by%20a%20second%20larger%20trial%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%3B%20n%3D108%29%20in%20middle-aged%20men%20and%20women%20focusing%20on%20wrinkle%20reduction.%20Healthy%20participants%20were%20included%20in%20the%20placebo-controlled%2C%20randomized%20UVB-induced%20trial%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20photo-damage%20trial%3B%20n%3D22%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%29.%20Participants%20were%20randomized%20to%20receive%20topical%20supplementation%20with%20either%200.5%25%20Urolithin%20A%20cream%20or%20placebo%20for%208-weeks%20in%20a%20low-dose%20arm%20or%201%25%20Urolithin%20A%20cream%20or%20placebo%20in%20the%20high-dose%20arm%20in%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20.%20In%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20participants%20were%20randomized%20to%20receive%201%25%20UA%20in%20a%20day-cream%2C%20a%20night%20cream%20and%20a%20serum%2C%20that%20were%20compared%20to%20the%20untreated%20site.%20For%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20photo-damage%20trial%2C%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20topical%20patches%20containing%20either%200.5%25%20or%201%25%20UA%20or%20placebo%20cream%20were%20applied%20for%2024-hours%20following%20UVB%20irradiation.%20The%20primary%20outcome%20in%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20was%20an%20impact%20on%20biological%20pathways%20linked%20to%20skin%20aging%20in%20skin%20biopsies%2C%20and%20an%20impact%20on%20skin%20barrier%20function%20after%208-weeks.%20Key%20secondary%20endpoints%20were%20a%20change%20in%20facial%20wrinkle%20appearance%20%28crow%5Cu2019s%20feet%20area%29.%20The%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20focused%20on%20wrinkle%20reduction%20as%20a%20primary%20outcome.%20In%20the%20UVB-mediated%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20photo-damage%20study%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%2C%20the%20primary%20read-out%20was%20the%20change%20in%20erythema%20after%20application.%20Molecular%20analyses%20were%20conducted%20on%20skin%20biopsies%20and%20using%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20ex-vivo%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20systems%20to%20investigate%20the%20mechanism%20of%20action%20mediating%20skin%20protective%20effects%20of%20Urolithin%20A.%20In%20the%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%2C%20Urolithin%20A%20at%201%25%20significantly%20up-regulated%20collagen%20synthesis%20pathways%20in%20human%20skin%20biopsies%20and%20led%20to%20a%20decrease%20in%20wrinkle%20depth%20on%20facial%20wrinkles.%20The%20lower%20dose%20had%20no%20significant%20impact.%20There%20was%20no%20change%20on%20skin%20barrier%20function%20with%20both%20doses%20suggesting%20maintenance%20of%20a%20healthy%20skin%20barrier%20function.%20In%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20aging%20study%202%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%2C%20topical%20application%20of%20Urolithin%20A%20at%20the%201%25%20dose%20in%20different%20formulations%20%28day-cream%2C%20night%20cream%20and%20serum%29%20led%20to%20significant%20wrinkle%20reduction%20compared%20to%20the%20untreated%20side%2C%20confirming%20the%20previous%20findings.%20Skin%20hydration%20was%20improved%20significantly%20as%20well.%20In%20the%20third%20trial%2C%20investigating%20impact%20on%20photodamaged%20skin%2C%20Urolithin%20A%20application%20led%20to%20a%20significant%20decrease%20in%20UV-induced%20erythema%20%28%5Cu223c14%25%29%20compared%20to%20the%20untreated%20area%2C%20while%20placebo%20and%20lower%20dose%20UA%20cream%5Cu2019s%20showed%20no%20benefits.%20Urolithin%20A%20topical%20administration%20was%20safe%20and%20well-tolerated%20in%20all%20studies.%20UA%20also%20inhibited%20collagen%20degrading%20and%20pro-inflammatory%20pathways%20and%20up-regulated%20gene%20expression%20of%20biomarkers%20linked%20to%20induction%20of%20mitophagy%20and%20autophagy%20in%20human%20skin%20cells.%20Taken%20together%2C%20these%20clinical%20studies%20support%20the%20topical%20use%20of%20Urolithin%20A%20to%20manage%20and%20prolong%20skin%20health%20longevity%20by%20acting%20at%20the%20cellular%20level%2C%20supporting%20collagen%20structure%2C%20reducing%20wrinkle%20appearance%20and%20protecting%20against%20photoaging.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20studies%20are%20registered%20in%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20clinicaltrials.gov%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20as%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20NCT05300984%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%3B%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20NCT05473832%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%3B%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20NCT05300542%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22%22%2C%22archiveID%22%3A%22%22%2C%22date%22%3A%222023-06-20%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.06.16.23291378%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fmedrxiv.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1101%5C%2F2023.06.16.23291378%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A34%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22F8FLPA2S%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222023-08-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20S.%2C%20Faitg%2C%20J.%2C%20Tissot%2C%20C.%2C%20Konstantopoulos%2C%20D.%2C%20Laws%2C%20R.%2C%20Bourdier%2C%20G.%2C%20Andreux%2C%20P.%20A.%2C%20Davey%2C%20T.%2C%20Singh%2C%20A.%2C%20Rinsch%2C%20C.%2C%20Marcinek%2C%20D.%20J.%2C%20%26amp%3B%20D%26%23x2019%3BAmico%2C%20D.%20%282023%29.%20%3Ci%3EUrolithin%20A%20induces%20cardioprotection%20and%20enhanced%20mitochondrial%20quality%20during%20natural%20aging%20and%20heart%20failure%3C%5C%2Fi%3E.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.08.22.554375%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2023.08.22.554375%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22Urolithin%20A%20induces%20cardioprotection%20and%20enhanced%20mitochondrial%20quality%20during%20natural%20aging%20and%20heart%20failure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Faitg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%22%2C%22lastName%22%3A%22Tissot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Konstantopoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Laws%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Bourdier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.A.%22%2C%22lastName%22%3A%22Andreux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Davey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Rinsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.J.%22%2C%22lastName%22%3A%22Marcinek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22D%5Cu2019Amico%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20Cardiovascular%20diseases%20remain%20the%20primary%20cause%20of%20global%20mortality%2C%20necessitating%20effective%20strategies%20to%20alleviate%20their%20burden.%20Mitochondrial%20dysfunction%20is%20a%20driving%20force%20behind%20aging%20and%20chronic%20conditions%2C%20including%20heart%20disease.%20Here%2C%20we%20investigate%20the%20potential%20of%20Urolithin%20A%20%28UA%29%2C%20a%20gut%20microbiome-derived%20postbiotic%20that%20enhances%20mitophagy%2C%20to%20ameliorate%20both%20age-related%20decline%20in%20cardiac%20function%20and%20cardiac%20failure.%20We%20highlight%20the%20significance%20of%20targeting%20mitochondria%2C%20by%20comparing%20gene%20expression%20changes%20in%20aging%20human%20hearts%20and%20cardiomyopathies.%20UA%20oral%20administration%20successfully%20counteracts%20mitochondrial%20and%20cardiac%20dysfunctions%20in%20preclinical%20models%20of%20aging%20and%20heart%20failure.%20UA%20improves%20both%20systolic%20and%20diastolic%20heart%20functions%2C%20distinguishing%20it%20from%20other%20mitochondrial%20interventions.%20In%20cardiomyocytes%2C%20UA%20recovers%20mitochondrial%20ultrastructural%20defects%20and%20decline%20in%20mitochondrial%20biomarkers%20occurring%20with%20aging%20and%20disease.%20These%20findings%20extend%20UA%5Cu2019s%20benefits%20to%20heart%20health%2C%20making%20UA%20a%20promising%20nutritional%20intervention%20to%20evaluate%20in%20the%20clinic%20to%20promote%20healthy%20cardiovascular%20function%20as%20we%20age.%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22%22%2C%22archiveID%22%3A%22%22%2C%22date%22%3A%222023-08-24%22%2C%22DOI%22%3A%2210.1101%5C%2F2023.08.22.554375%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fbiorxiv.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1101%5C%2F2023.08.22.554375%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A34%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22FWE8XMUV%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Finsterwald%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EFinsterwald%2C%20C.%2C%20Dias%2C%20S.%2C%20Magistretti%2C%20P.%20J.%2C%20%26amp%3B%20Lengacher%2C%20S.%20%282021%29.%20Ganglioside%20GM1%20Targets%20Astrocytes%20to%20Stimulate%20Cerebral%20Energy%20Metabolism.%20%3Ci%3EFrontiers%20in%20Pharmacology%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%2C%20653842.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffphar.2021.653842%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffphar.2021.653842%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ganglioside%20GM1%20Targets%20Astrocytes%20to%20Stimulate%20Cerebral%20Energy%20Metabolism%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%22%2C%22lastName%22%3A%22Finsterwald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Dias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pierre%20J.%22%2C%22lastName%22%3A%22Magistretti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvain%22%2C%22lastName%22%3A%22Lengacher%22%7D%5D%2C%22abstractNote%22%3A%22Gangliosides%20are%20major%20constituents%20of%20the%20plasma%20membrane%20and%20are%20known%20to%20promote%20a%20number%20of%20physiological%20actions%20in%20the%20brain%2C%20including%20synaptic%20plasticity%20and%20neuroprotection.%20In%20particular%2C%20the%20ganglioside%20GM1%20was%20found%20to%20have%20a%20wide%20range%20of%20preclinical%20and%20clinical%20benefits%20in%20brain%20diseases%20such%20as%20spinal%20cord%20injury%2C%20Huntington%5Cu2019s%20disease%20and%20Parkinson%5Cu2019s%20disease.%20However%2C%20little%20is%20known%20about%20the%20underlying%20cellular%20and%20molecular%20mechanisms%20of%20GM1%20in%20the%20brain.%20In%20the%20present%20study%2C%20we%20show%20that%20GM1%20exerts%20its%20actions%20through%20the%20promotion%20of%20glycolysis%20in%20astrocytes%2C%20which%20leads%20to%20glucose%20uptake%20and%20lactate%20release%20by%20these%20cells.%20In%20astrocytes%2C%20GM1%20stimulates%20the%20expression%20of%20several%20genes%20involved%20in%20the%20regulation%20of%20glucose%20metabolism.%20GM1%20also%20enhances%20neuronal%20mitochondrial%20activity%20and%20triggers%20the%20expression%20of%20neuroprotection%20genes%20when%20neurons%20are%20cultured%20in%20the%20presence%20of%20astrocytes.%20Finally%2C%20GM1%20leads%20to%20a%20neuroprotective%20effect%20in%20astrocyte-neuron%20co-culture.%20Together%2C%20these%20data%20identify%20a%20previously%20unrecognized%20mechanism%20mediated%20by%20astrocytes%20by%20which%20GM1%20exerts%20its%20metabolic%20and%20neuroprotective%20effects.%22%2C%22date%22%3A%222021-4-28%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffphar.2021.653842%22%2C%22ISSN%22%3A%221663-9812%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffphar.2021.653842%5C%2Ffull%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A34%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22JGRCF46M%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sipion%20et%20al.%22%2C%22parsedDate%22%3A%222023-11-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESipion%2C%20M.%2C%20Ferreira%2C%20F.%20M.%2C%20Scholler%2C%20J.%2C%20Brana%2C%20C.%2C%20Gora%2C%20M.%2C%20Kouvas%2C%20G.%2C%20Barthet%2C%20G.%2C%20%26amp%3B%20Sobolewski%2C%20A.%20%282023%29.%20A%20randomized%2C%20blinded%20study%20of%20photobiomodulation%20in%20a%20mouse%20model%20of%20Alzheimer%26%23x2019%3Bs%20disease%20showed%20no%20preventive%20effect.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%281%29%2C%2019828.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-47039-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-47039-2%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20randomized%2C%20blinded%20study%20of%20photobiomodulation%20in%20a%20mouse%20model%20of%20Alzheimer%5Cu2019s%20disease%20showed%20no%20preventive%20effect%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%5Cu00e9lanie%22%2C%22lastName%22%3A%22Sipion%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Filipa%20M.%22%2C%22lastName%22%3A%22Ferreira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jules%22%2C%22lastName%22%3A%22Scholler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Corinne%22%2C%22lastName%22%3A%22Brana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michalina%22%2C%22lastName%22%3A%22Gora%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22George%22%2C%22lastName%22%3A%22Kouvas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gael%22%2C%22lastName%22%3A%22Barthet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aleksander%22%2C%22lastName%22%3A%22Sobolewski%22%7D%5D%2C%22abstractNote%22%3A%22Photobiomodulation%20%28PBM%29%2C%20the%20process%20of%20exposing%20tissue%20to%20red%20or%20near-infrared%20light%2C%20has%20become%20a%20topic%20of%20great%20interest%20as%20a%20therapy%20for%20diverse%20pathologies%2C%20including%20neurodegenerative%20disorders.%20Here%2C%20we%20aimed%20to%20evaluate%20the%20potential%20beneficial%20effect%20of%20PBM%20on%20Alzheimer%5Cu2019s%20disease%20%28AD%29%20using%20behavioral%20and%20histological%20readouts%20from%20a%20well-established%20transgenic%20murine%20AD%20model%20%285xFAD%20mice%29%20in%20a%20randomized%20and%20fully%20blinded%20long-term%20in-vivo%20study%20following%20GLP%20%28Good%20Laboratory%20Practices%29%20guidelines.%20The%20heads%20of%20the%20mice%20were%20illuminated%20with%20no%20%28sham%29%2C%20low%20or%20high%20power%20810%5Cu00a0nm%20light%2C%20three%20times%20a%20week%20for%205%5Cu00a0months%20from%20the%20first%20to%20the%20sixth%20month%20of%20life%20corresponding%20to%20the%20prodromal%20phase%20of%20the%20pathology.%20The%20results%20showed%20that%20there%20were%20no%20significant%20differences%20between%20the%20groups%20in%20behavioral%20tests%2C%20including%20the%20Morris%20water%20maze%2C%20novel%20object%20recognition%2C%20and%20Y-maze.%20Similarly%2C%20histological%20analyses%20showed%20no%20differences%20in%20amyloid%20load%2C%20neuronal%20loss%20or%20microglial%20response.%20In%20conclusion%2C%20under%20the%20conditions%20of%20our%20experiment%2C%20we%20were%20unable%20to%20demonstrate%20any%20therapeutic%20effect%20of%20PBM%20for%20AD.%20This%20study%20calls%20for%20further%20evidence%20and%20caution%20when%20considering%20PBM%20as%20an%20effective%20treatment%20for%20AD.%22%2C%22date%22%3A%222023-11-14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-47039-2%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-023-47039-2%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A33%3A34Z%22%7D%7D%2C%7B%22key%22%3A%2255PFLUUZ%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ye%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYe%2C%20S.%2C%20Lauer%2C%20J.%2C%20Zhou%2C%20M.%2C%20Mathis%2C%20A.%2C%20%26amp%3B%20Mathis%2C%20M.%20W.%20%282023%29.%20%3Ci%3EAmadeusGPT%3A%20a%20natural%20language%20interface%20for%20interactive%20animal%20behavioral%20analysis%3C%5C%2Fi%3E.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.48550%5C%2FARXIV.2307.04858%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.48550%5C%2FARXIV.2307.04858%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22AmadeusGPT%3A%20a%20natural%20language%20interface%20for%20interactive%20animal%20behavioral%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaokai%22%2C%22lastName%22%3A%22Ye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessy%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mu%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Mathis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mackenzie%20W.%22%2C%22lastName%22%3A%22Mathis%22%7D%5D%2C%22abstractNote%22%3A%22The%20process%20of%20quantifying%20and%20analyzing%20animal%20behavior%20involves%20translating%20the%20naturally%20occurring%20descriptive%20language%20of%20their%20actions%20into%20machine-readable%20code.%20Yet%2C%20codifying%20behavior%20analysis%20is%20often%20challenging%20without%20deep%20understanding%20of%20animal%20behavior%20and%20technical%20machine%20learning%20knowledge.%20To%20limit%20this%20gap%2C%20we%20introduce%20AmadeusGPT%3A%20a%20natural%20language%20interface%20that%20turns%20natural%20language%20descriptions%20of%20behaviors%20into%20machine-executable%20code.%20Large-language%20models%20%28LLMs%29%20such%20as%20GPT3.5%20and%20GPT4%20allow%20for%20interactive%20language-based%20queries%20that%20are%20potentially%20well%20suited%20for%20making%20interactive%20behavior%20analysis.%20However%2C%20the%20comprehension%20capability%20of%20these%20LLMs%20is%20limited%20by%20the%20context%20window%20size%2C%20which%20prevents%20it%20from%20remembering%20distant%20conversations.%20To%20overcome%20the%20context%20window%20limitation%2C%20we%20implement%20a%20novel%20dual-memory%20mechanism%20to%20allow%20communication%20between%20short-term%20and%20long-term%20memory%20using%20symbols%20as%20context%20pointers%20for%20retrieval%20and%20saving.%20Concretely%2C%20users%20directly%20use%20language-based%20definitions%20of%20behavior%20and%20our%20augmented%20GPT%20develops%20code%20based%20on%20the%20core%20AmadeusGPT%20API%2C%20which%20contains%20machine%20learning%2C%20computer%20vision%2C%20spatio-temporal%20reasoning%2C%20and%20visualization%20modules.%20Users%20then%20can%20interactively%20refine%20results%2C%20and%20seamlessly%20add%20new%20behavioral%20modules%20as%20needed.%20We%20benchmark%20AmadeusGPT%20and%20show%20we%20can%20produce%20state-of-the-art%20performance%20on%20the%20MABE%202022%20behavior%20challenge%20tasks.%20Note%2C%20an%20end-user%20would%20not%20need%20to%20write%20any%20code%20to%20achieve%20this.%20Thus%2C%20collectively%20AmadeusGPT%20presents%20a%20novel%20way%20to%20merge%20deep%20biological%20knowledge%2C%20large-language%20models%2C%20and%20core%20computer%20vision%20modules%20into%20a%20more%20naturally%20intelligent%20system.%20Code%20and%20demos%20can%20be%20found%20at%3A%20https%3A%5C%2F%5C%2Fgithub.com%5C%2FAdaptiveMotorControlLab%5C%2FAmadeusGPT.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.48550%5C%2FARXIV.2307.04858%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farxiv.org%5C%2Fabs%5C%2F2307.04858%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A33%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22CTHZ7YGH%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ye%20et%20al.%22%2C%22parsedDate%22%3A%222024-06-21%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EYe%2C%20S.%2C%20Filippova%2C%20A.%2C%20Lauer%2C%20J.%2C%20Schneider%2C%20S.%2C%20Vidal%2C%20M.%2C%20Qiu%2C%20T.%2C%20Mathis%2C%20A.%2C%20%26amp%3B%20Mathis%2C%20M.%20W.%20%282024%29.%20SuperAnimal%20pretrained%20pose%20estimation%20models%20for%20behavioral%20analysis.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E15%3C%5C%2Fi%3E%281%29%2C%205165.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-48792-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-024-48792-2%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SuperAnimal%20pretrained%20pose%20estimation%20models%20for%20behavioral%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shaokai%22%2C%22lastName%22%3A%22Ye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastasiia%22%2C%22lastName%22%3A%22Filippova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessy%22%2C%22lastName%22%3A%22Lauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffen%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Vidal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tian%22%2C%22lastName%22%3A%22Qiu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Mathis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mackenzie%20Weygandt%22%2C%22lastName%22%3A%22Mathis%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Quantification%20of%20behavior%20is%20critical%20in%20diverse%20applications%20from%20neuroscience%2C%20veterinary%20medicine%20to%20animal%20conservation.%20A%20common%20key%20step%20for%20behavioral%20analysis%20is%20first%20extracting%20relevant%20keypoints%20on%20animals%2C%20known%20as%20pose%20estimation.%20However%2C%20reliable%20inference%20of%20poses%20currently%20requires%20domain%20knowledge%20and%20manual%20labeling%20effort%20to%20build%20supervised%20models.%20We%20present%20SuperAnimal%2C%20a%20method%20to%20develop%20unified%20foundation%20models%20that%20can%20be%20used%20on%20over%2045%20species%2C%20without%20additional%20manual%20labels.%20These%20models%20show%20excellent%20performance%20across%20six%20pose%20estimation%20benchmarks.%20We%20demonstrate%20how%20to%20fine-tune%20the%20models%20%28if%20needed%29%20on%20differently%20labeled%20data%20and%20provide%20tooling%20for%20unsupervised%20video%20adaptation%20to%20boost%20performance%20and%20decrease%20jitter%20across%20frames.%20If%20fine-tuned%2C%20SuperAnimal%20models%20are%2010%5Cu2013100%5Cu00d7%20more%20data%20efficient%20than%20prior%20transfer-learning-based%20approaches.%20We%20illustrate%20the%20utility%20of%20our%20models%20in%20behavioral%20classification%20and%20kinematic%20analysis.%20Collectively%2C%20we%20present%20a%20data-efficient%20solution%20for%20animal%20pose%20estimation.%22%2C%22date%22%3A%222024-06-21%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-024-48792-2%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-024-48792-2%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A32%3A21Z%22%7D%7D%2C%7B%22key%22%3A%227VI7LEML%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Achard%20et%20al.%22%2C%22parsedDate%22%3A%222024-05-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAchard%2C%20C.%2C%20Kousi%2C%20T.%2C%20Frey%2C%20M.%2C%20Vidal%2C%20M.%2C%20Paych%26%23xE8%3Bre%2C%20Y.%2C%20Hofmann%2C%20C.%2C%20Iqbal%2C%20A.%2C%20Hausmann%2C%20S.%20B.%2C%20Pag%26%23xE8%3Bs%2C%20S.%2C%20%26amp%3B%20Mathis%2C%20M.%20W.%20%282024%29.%20%3Ci%3ECellSeg3D%3A%20self-supervised%203D%20cell%20segmentation%20for%20microscopy%3C%5C%2Fi%3E.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.05.17.594691%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.05.17.594691%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22CellSeg3D%3A%20self-supervised%203D%20cell%20segmentation%20for%20microscopy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyril%22%2C%22lastName%22%3A%22Achard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timokleia%22%2C%22lastName%22%3A%22Kousi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Frey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Vidal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yves%22%2C%22lastName%22%3A%22Paych%5Cu00e8re%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Colin%22%2C%22lastName%22%3A%22Hofmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Asim%22%2C%22lastName%22%3A%22Iqbal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastien%20B.%22%2C%22lastName%22%3A%22Hausmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phane%22%2C%22lastName%22%3A%22Pag%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mackenzie%20Weygandt%22%2C%22lastName%22%3A%22Mathis%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20Understanding%20the%20complex%20three-dimensional%20structure%20of%20cells%20is%20crucial%20across%20many%20disciplines%20in%20biology%20and%20especially%20in%20neuroscience.%20Here%2C%20we%20introduce%20a%20novel%203D%20self-supervised%20learning%20method%20designed%20to%20address%20the%20inherent%20complexity%20of%20quantifying%20cells%20in%203D%20volumes%2C%20often%20in%20cleared%20neural%20tissue.%20We%20offer%20a%20new%203D%20mesoSPIM%20dataset%20and%20show%20that%20CellSeg3D%20can%20match%20state-of-the-art%20supervised%20methods.%20Our%20contributions%20are%20made%20accessible%20through%20a%20Python%20package%20with%20full%20GUI%20integration%20in%20napari.%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22%22%2C%22archiveID%22%3A%22%22%2C%22date%22%3A%222024-05-17%22%2C%22DOI%22%3A%2210.1101%5C%2F2024.05.17.594691%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fbiorxiv.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1101%5C%2F2024.05.17.594691%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A31%3A55Z%22%7D%7D%2C%7B%22key%22%3A%2256UJKT7J%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vachicouras%20et%20al.%22%2C%22parsedDate%22%3A%222019-10-16%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVachicouras%2C%20N.%2C%20Tarabichi%2C%20O.%2C%20Kanumuri%2C%20V.%20V.%2C%20Tringides%2C%20C.%20M.%2C%20Macron%2C%20J.%2C%20Fallegger%2C%20F.%2C%20Thenaisie%2C%20Y.%2C%20Epprecht%2C%20L.%2C%20McInturff%2C%20S.%2C%20Qureshi%2C%20A.%20A.%2C%20Paggi%2C%20V.%2C%20Kuklinski%2C%20M.%20W.%2C%20Brown%2C%20M.%20C.%2C%20Lee%2C%20D.%20J.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282019%29.%20Microstructured%20thin-film%20electrode%20technology%20enables%20proof%20of%20concept%20of%20scalable%2C%20soft%20auditory%20brainstem%20implants.%20%3Ci%3EScience%20Translational%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%28514%29%2C%20eaax9487.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aax9487%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aax9487%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Microstructured%20thin-film%20electrode%20technology%20enables%20proof%20of%20concept%20of%20scalable%2C%20soft%20auditory%20brainstem%20implants%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vachicouras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Osama%22%2C%22lastName%22%3A%22Tarabichi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivek%20V.%22%2C%22lastName%22%3A%22Kanumuri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%20M.%22%2C%22lastName%22%3A%22Tringides%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jennifer%22%2C%22lastName%22%3A%22Macron%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yohann%22%2C%22lastName%22%3A%22Thenaisie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenz%22%2C%22lastName%22%3A%22Epprecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22McInturff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahad%20A.%22%2C%22lastName%22%3A%22Qureshi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Paggi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%20W.%22%2C%22lastName%22%3A%22Kuklinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%20Christian%22%2C%22lastName%22%3A%22Brown%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20J.%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Engineered%20conformability%20in%20auditory%20brainstem%20implant%20electrode%20arrays%20improves%20the%20electrode-brainstem%20interface%20in%20mice%20and%20in%20human%20cadavers.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Beneficial%20bending%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Some%20people%20with%20deafness%20receive%20auditory%20brainstem%20implants%20%28ABIs%29%2C%20neurotechnology%20that%20directly%20stimulates%20the%20cochlear%20nucleus%20%28CN%29.%20Unfortunately%2C%20auditory%20outcomes%20after%20implantation%20are%20limited%2C%20possibly%20due%20to%20mismatch%20between%20the%20stiffness%20of%20the%20implant%20and%20the%20CN.%20Vachicouras%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20et%20al%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20developed%20ABIs%20that%20conform%20to%20the%20curvature%20of%20the%20CN.%20The%20soft%20arrays%20could%20be%20easily%20handled%20during%20surgery%20and%20functioned%20over%201%20month%20when%20implanted%20in%20mice.%20A%20scaled-up%20version%20of%20the%20conformable%20ABIs%20inserted%20in%20human%20cadavers%20showed%20good%20electromechanical%20and%20electrochemical%20stability%20and%20a%20potentially%20larger%20dynamic%20range%20compared%20to%20the%20clinical%20ABIs.%20These%20proof-of-concept%20results%20support%20further%20testing%20in%20models%20of%20deafness.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Auditory%20brainstem%20implants%20%28ABIs%29%20provide%20sound%20awareness%20to%20deaf%20individuals%20who%20are%20not%20candidates%20for%20the%20cochlear%20implant.%20The%20ABI%20electrode%20array%20rests%20on%20the%20surface%20of%20the%20cochlear%20nucleus%20%28CN%29%20in%20the%20brainstem%20and%20delivers%20multichannel%20electrical%20stimulation.%20The%20complex%20anatomy%20and%20physiology%20of%20the%20CN%2C%20together%20with%20poor%20spatial%20selectivity%20of%20electrical%20stimulation%20and%20inherent%20stiffness%20of%20contemporary%20multichannel%20arrays%2C%20leads%20to%20only%20modest%20auditory%20outcomes%20among%20ABI%20users.%20Here%2C%20we%20hypothesized%20that%20a%20soft%20ABI%20could%20enhance%20biomechanical%20compatibility%20with%20the%20curved%20CN%20surface.%20We%20developed%20implantable%20ABIs%20that%20are%20compatible%20with%20surgical%20handling%2C%20conform%20to%20the%20curvature%20of%20the%20CN%20after%20placement%2C%20and%20deliver%20efficient%20electrical%20stimulation.%20The%20soft%20ABI%20array%20design%20relies%20on%20precise%20microstructuring%20of%20plastic-metal-plastic%20multilayers%20to%20enable%20mechanical%20compliance%2C%20patterning%2C%20and%20electrical%20function.%20We%20fabricated%20soft%20ABIs%20to%20the%20scale%20of%20mouse%20and%20human%20CN%20and%20validated%20them%20in%20vitro.%20Experiments%20in%20mice%20demonstrated%20that%20these%20implants%20reliably%20evoked%20auditory%20neural%20activity%20over%201%20month%20in%20vivo.%20Evaluation%20in%20human%20cadaveric%20models%20confirmed%20compatibility%20after%20insertion%20using%20an%20endoscopic-assisted%20craniotomy%20surgery%2C%20ease%20of%20array%20positioning%2C%20and%20robustness%20and%20reliability%20of%20the%20soft%20electrodes.%20This%20neurotechnology%20offers%20an%20opportunity%20to%20treat%20deafness%20in%20patients%20who%20are%20not%20candidates%20for%20the%20cochlear%20implant%2C%20and%20the%20design%20and%20manufacturing%20principles%20are%20broadly%20applicable%20to%20implantable%20soft%20bioelectronics%20throughout%20the%20central%20and%20peripheral%20nervous%20system.%22%2C%22date%22%3A%222019-10-16%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscitranslmed.aax9487%22%2C%22ISSN%22%3A%221946-6234%2C%201946-6242%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fscitranslmed.aax9487%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A31%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22BIUIPX3U%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shur%20et%20al.%22%2C%22parsedDate%22%3A%222020-07-20%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EShur%2C%20M.%2C%20Fallegger%2C%20F.%2C%20Pirondini%2C%20E.%2C%20Roux%2C%20A.%2C%20Bichat%2C%20A.%2C%20Barraud%2C%20Q.%2C%20Courtine%2C%20G.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282020%29.%20Soft%20Printable%20Electrode%20Coating%20for%20Neural%20Interfaces.%20%3Ci%3EACS%20Applied%20Bio%20Materials%3C%5C%2Fi%3E%2C%20%3Ci%3E3%3C%5C%2Fi%3E%287%29%2C%204388%26%23x2013%3B4397.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsabm.0c00401%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1021%5C%2Facsabm.0c00401%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Soft%20Printable%20Electrode%20Coating%20for%20Neural%20Interfaces%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Shur%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Pirondini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrien%22%2C%22lastName%22%3A%22Roux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Bichat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020-07-20%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1021%5C%2Facsabm.0c00401%22%2C%22ISSN%22%3A%222576-6422%2C%202576-6422%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.acs.org%5C%2Fdoi%5C%2F10.1021%5C%2Facsabm.0c00401%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A30%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22K4HAM7IT%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Paggi%20et%20al.%22%2C%22parsedDate%22%3A%222024-02-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPaggi%2C%20V.%2C%20Fallegger%2C%20F.%2C%20Serex%2C%20L.%2C%20Rizzo%2C%20O.%2C%20Galan%2C%20K.%2C%20Giannotti%2C%20A.%2C%20Furfaro%2C%20I.%2C%20Zinno%2C%20C.%2C%20Bernini%2C%20F.%2C%20Micera%2C%20S.%2C%20%26amp%3B%20Lacour%2C%20S.%20P.%20%282024%29.%20A%20soft%2C%20scalable%20and%20adaptable%20multi-contact%20cuff%20electrode%20for%20targeted%20peripheral%20nerve%20modulation.%20%3Ci%3EBioelectronic%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E10%3C%5C%2Fi%3E%281%29%2C%206.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs42234-023-00137-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs42234-023-00137-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20soft%2C%20scalable%20and%20adaptable%20multi-contact%20cuff%20electrode%20for%20targeted%20peripheral%20nerve%20modulation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Paggi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludovic%22%2C%22lastName%22%3A%22Serex%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivier%22%2C%22lastName%22%3A%22Rizzo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katia%22%2C%22lastName%22%3A%22Galan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Giannotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Furfaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ciro%22%2C%22lastName%22%3A%22Zinno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%22%2C%22lastName%22%3A%22Bernini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Cuff%20electrodes%20target%20various%20nerves%20throughout%20the%20body%2C%20providing%20neuromodulation%20therapies%20for%20motor%2C%20sensory%2C%20or%20autonomic%20disorders.%20However%2C%20when%20using%20standard%2C%20thick%20silicone%20cuffs%2C%20fabricated%20in%20discrete%20circular%20sizes%2C%20complications%20may%20arise%2C%20namely%20cuff%20displacement%20or%20nerve%20compression%2C%20due%20to%20a%20poor%20adaptability%20to%20variable%20nerve%20shapes%20and%20sizes%20encountered%20in%20vivo.%20Improvements%20in%20cuff%20design%2C%20materials%2C%20closing%20mechanism%20and%20surgical%20approach%20are%20necessary%20to%20overcome%20these%20issues.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20this%20work%2C%20we%20propose%20a%20microfabricated%20multi-channel%20silicone-based%20soft%20cuff%20electrode%20with%20a%20novel%20easy-to-implant%20and%20size-adaptable%20design%20and%20evaluate%20a%20number%20of%20essential%20features%20such%20as%20nerve-cuff%20contact%2C%20nerve%20compression%2C%20cuff%20locking%20stability%2C%20long-term%20integration%20and%20stimulation%20selectivity.%20We%20also%20compared%20performance%20to%20that%20of%20standard%20fixed-size%20cuffs.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20belt-like%20cuff%20made%20of%20150%5Cu2009%5Cu03bcm%20thick%20silicone%20membranes%20provides%20a%20stable%20and%20pressure-free%20conformal%20contact%2C%20independently%20of%20nerve%20size%20variability%2C%20combined%20with%20a%20straightforward%20implantation%20procedure.%20The%20adaptable%20design%20and%20use%20of%20soft%20materials%20lead%20to%20limited%20scarring%20and%20demyelination%20after%206-week%20implantation.%20In%20addition%2C%20multi-contact%20designs%2C%20ranging%20from%206%20to%2016%20electrodes%2C%20allow%20for%20selective%20stimulation%20in%20models%20of%20rat%20and%20pig%20sciatic%20nerve%2C%20achieving%20targeted%20activation%20of%20up%20to%205%20hindlimb%20muscles.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20These%20results%20suggest%20a%20promising%20alternative%20to%20classic%20fixed-diameter%20cuffs%20and%20may%20facilitate%20the%20adoption%20of%20soft%2C%20adaptable%20cuffs%20in%20clinical%20settings.%22%2C%22date%22%3A%222024-02-14%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs42234-023-00137-y%22%2C%22ISSN%22%3A%222332-8886%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbioelecmed.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs42234-023-00137-y%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%2C%22HSR6CV29%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A29%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22RMV8CFEY%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Von%20Zitzewitz%20et%20al.%22%2C%22parsedDate%22%3A%222016-04-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EVon%20Zitzewitz%2C%20J.%2C%20Asboth%2C%20L.%2C%20Fumeaux%2C%20N.%2C%20Hasse%2C%20A.%2C%20Baud%2C%20L.%2C%20Vallery%2C%20H.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282016%29.%20A%20neurorobotic%20platform%20for%20locomotor%20prosthetic%20development%20in%20rats%20and%20mice.%20%3Ci%3EJournal%20of%20Neural%20Engineering%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%282%29%2C%20026007.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1741-2560%5C%2F13%5C%2F2%5C%2F026007%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1088%5C%2F1741-2560%5C%2F13%5C%2F2%5C%2F026007%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20neurorobotic%20platform%20for%20locomotor%20prosthetic%20development%20in%20rats%20and%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joachim%22%2C%22lastName%22%3A%22Von%20Zitzewitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Fumeaux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Hasse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heike%22%2C%22lastName%22%3A%22Vallery%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222016-04-01%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1088%5C%2F1741-2560%5C%2F13%5C%2F2%5C%2F026007%22%2C%22ISSN%22%3A%221741-2560%2C%201741-2552%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fiopscience.iop.org%5C%2Farticle%5C%2F10.1088%5C%2F1741-2560%5C%2F13%5C%2F2%5C%2F026007%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A29%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22TSAPZDGW%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wurth%20et%20al.%22%2C%22parsedDate%22%3A%222017%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWurth%2C%20S.%2C%20Capogrosso%2C%20M.%2C%20Raspopovic%2C%20S.%2C%20Gandar%2C%20J.%2C%20Federici%2C%20G.%2C%20Kinany%2C%20N.%2C%20Cutrone%2C%20A.%2C%20Piersigilli%2C%20A.%2C%20Pavlova%2C%20N.%2C%20Guiet%2C%20R.%2C%20Taverni%2C%20G.%2C%20Rigosa%2C%20J.%2C%20Shkorbatova%2C%20P.%2C%20Navarro%2C%20X.%2C%20Barraud%2C%20Q.%2C%20Courtine%2C%20G.%2C%20%26amp%3B%20Micera%2C%20S.%20%282017%29.%20Long-term%20usability%20and%20bio-integration%20of%20polyimide-based%20intra-neural%20stimulating%20electrodes.%20%3Ci%3EBiomaterials%3C%5C%2Fi%3E%2C%20%3Ci%3E122%3C%5C%2Fi%3E%2C%20114%26%23x2013%3B129.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2017.01.014%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2017.01.014%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Long-term%20usability%20and%20bio-integration%20of%20polyimide-based%20intra-neural%20stimulating%20electrodes%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Wurth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Raspopovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Gandar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Federici%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Kinany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Cutrone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Piersigilli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Pavlova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Guiet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Taverni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Rigosa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22P.%22%2C%22lastName%22%3A%22Shkorbatova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22X.%22%2C%22lastName%22%3A%22Navarro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Q.%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Micera%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2204%5C%2F2017%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.biomaterials.2017.01.014%22%2C%22ISSN%22%3A%2201429612%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0142961217300224%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A29%3A01Z%22%7D%7D%2C%7B%22key%22%3A%22MLNB5Y7D%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Asboth%20et%20al.%22%2C%22parsedDate%22%3A%222018%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAsboth%2C%20L.%2C%20Friedli%2C%20L.%2C%20Beauparlant%2C%20J.%2C%20Martinez-Gonzalez%2C%20C.%2C%20Anil%2C%20S.%2C%20Rey%2C%20E.%2C%20Baud%2C%20L.%2C%20Pidpruzhnykova%2C%20G.%2C%20Anderson%2C%20M.%20A.%2C%20Shkorbatova%2C%20P.%2C%20Batti%2C%20L.%2C%20Pag%26%23xE8%3Bs%2C%20S.%2C%20Kreider%2C%20J.%2C%20Schneider%2C%20B.%20L.%2C%20Barraud%2C%20Q.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282018%29.%20Cortico%26%23x2013%3Breticulo%26%23x2013%3Bspinal%20circuit%20reorganization%20enables%20functional%20recovery%20after%20severe%20spinal%20cord%20contusion.%20%3Ci%3ENature%20Neuroscience%3C%5C%2Fi%3E%2C%20%3Ci%3E21%3C%5C%2Fi%3E%284%29%2C%20576%26%23x2013%3B588.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-018-0093-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-018-0093-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cortico%5Cu2013reticulo%5Cu2013spinal%20circuit%20reorganization%20enables%20functional%20recovery%20after%20severe%20spinal%20cord%20contusion%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lucia%22%2C%22lastName%22%3A%22Friedli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janine%22%2C%22lastName%22%3A%22Beauparlant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Martinez-Gonzalez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Selin%22%2C%22lastName%22%3A%22Anil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Rey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Galyna%22%2C%22lastName%22%3A%22Pidpruzhnykova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polina%22%2C%22lastName%22%3A%22Shkorbatova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Batti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephane%22%2C%22lastName%22%3A%22Pag%5Cu00e8s%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Kreider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernard%20L.%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%224%5C%2F2018%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41593-018-0093-5%22%2C%22ISSN%22%3A%221097-6256%2C%201546-1726%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41593-018-0093-5%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A28%3A44Z%22%7D%7D%2C%7B%22key%22%3A%22NLFBUEGB%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bonizzato%20et%20al.%22%2C%22parsedDate%22%3A%222018-08-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBonizzato%2C%20M.%2C%20Pidpruzhnykova%2C%20G.%2C%20DiGiovanna%2C%20J.%2C%20Shkorbatova%2C%20P.%2C%20Pavlova%2C%20N.%2C%20Micera%2C%20S.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282018%29.%20Brain-controlled%20modulation%20of%20spinal%20circuits%20improves%20recovery%20from%20spinal%20cord%20injury.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E9%3C%5C%2Fi%3E%281%29%2C%203015.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-05282-6%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-018-05282-6%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Brain-controlled%20modulation%20of%20spinal%20circuits%20improves%20recovery%20from%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Bonizzato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Galyna%22%2C%22lastName%22%3A%22Pidpruzhnykova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%22%2C%22lastName%22%3A%22DiGiovanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polina%22%2C%22lastName%22%3A%22Shkorbatova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Pavlova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20delivery%20of%20brain-controlled%20neuromodulation%20therapies%20during%20motor%20rehabilitation%20may%20augment%20recovery%20from%20neurological%20disorders.%20To%20test%20this%20hypothesis%2C%20we%20conceived%20a%20brain-controlled%20neuromodulation%20therapy%20that%20combines%20the%20technical%20and%20practical%20features%20necessary%20to%20be%20deployed%20daily%20during%20gait%20rehabilitation.%20Rats%20received%20a%20severe%20spinal%20cord%20contusion%20that%20led%20to%20leg%20paralysis.%20We%20engineered%20a%20proportional%20brain%5Cu2013spine%20interface%20whereby%20cortical%20ensemble%20activity%20constantly%20determines%20the%20amplitude%20of%20spinal%20cord%20stimulation%20protocols%20promoting%20leg%20flexion%20during%20swing.%20After%20minimal%20calibration%20time%20and%20without%20prior%20training%2C%20this%20neural%20bypass%20enables%20paralyzed%20rats%20to%20walk%20overground%20and%20adjust%20foot%20clearance%20in%20order%20to%20climb%20a%20staircase.%20Compared%20to%20continuous%20spinal%20cord%20stimulation%2C%20brain-controlled%20stimulation%20accelerates%20and%20enhances%20the%20long-term%20recovery%20of%20locomotion.%20These%20results%20demonstrate%20the%20relevance%20of%20brain-controlled%20neuromodulation%20therapies%20to%20augment%20recovery%20from%20motor%20disorders%2C%20establishing%20important%20proofs-of-concept%20that%20warrant%20clinical%20studies.%22%2C%22date%22%3A%222018-08-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-018-05282-6%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-018-05282-6%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A28%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22D3Y8GN8C%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hutson%20et%20al.%22%2C%22parsedDate%22%3A%222019-04-10%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHutson%2C%20T.%20H.%2C%20Kathe%2C%20C.%2C%20Palmisano%2C%20I.%2C%20Bartholdi%2C%20K.%2C%20Hervera%2C%20A.%2C%20De%20Virgiliis%2C%20F.%2C%20McLachlan%2C%20E.%2C%20Zhou%2C%20L.%2C%20Kong%2C%20G.%2C%20Barraud%2C%20Q.%2C%20Danzi%2C%20M.%20C.%2C%20Medrano-Fernandez%2C%20A.%2C%20Lopez-Atalaya%2C%20J.%20P.%2C%20Boutillier%2C%20A.%20L.%2C%20Sinha%2C%20S.%20H.%2C%20Singh%2C%20A.%20K.%2C%20Chaturbedy%2C%20P.%2C%20Moon%2C%20L.%20D.%20F.%2C%20Kundu%2C%20T.%20K.%2C%20%26%23x2026%3B%20Di%20Giovanni%2C%20S.%20%282019%29.%20Cbp-dependent%20histone%20acetylation%20mediates%20axon%20regeneration%20induced%20by%20environmental%20enrichment%20in%20rodent%20spinal%20cord%20injury%20models.%20%3Ci%3EScience%20Translational%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%28487%29%2C%20eaaw2064.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aaw2064%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aaw2064%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cbp-dependent%20histone%20acetylation%20mediates%20axon%20regeneration%20induced%20by%20environmental%20enrichment%20in%20rodent%20spinal%20cord%20injury%20models%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilaria%22%2C%22lastName%22%3A%22Palmisano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kay%22%2C%22lastName%22%3A%22Bartholdi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnau%22%2C%22lastName%22%3A%22Hervera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesco%22%2C%22lastName%22%3A%22De%20Virgiliis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eilidh%22%2C%22lastName%22%3A%22McLachlan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luming%22%2C%22lastName%22%3A%22Zhou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guiping%22%2C%22lastName%22%3A%22Kong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matt%20C.%22%2C%22lastName%22%3A%22Danzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%22%2C%22lastName%22%3A%22Medrano-Fernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20P.%22%2C%22lastName%22%3A%22Lopez-Atalaya%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%20L.%22%2C%22lastName%22%3A%22Boutillier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarmistha%20H.%22%2C%22lastName%22%3A%22Sinha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Akash%20K.%22%2C%22lastName%22%3A%22Singh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Piyush%22%2C%22lastName%22%3A%22Chaturbedy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lawrence%20D.%20F.%22%2C%22lastName%22%3A%22Moon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tapas%20K.%22%2C%22lastName%22%3A%22Kundu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20L.%22%2C%22lastName%22%3A%22Bixby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vance%20P.%22%2C%22lastName%22%3A%22Lemmon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angel%22%2C%22lastName%22%3A%22Barco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Di%20Giovanni%22%7D%5D%2C%22abstractNote%22%3A%22Environmental%20enrichment%20induces%20activity-dependent%20histone%20acetylation%20via%20a%20druggable%20mechanism%20to%20promote%20recovery%20after%20spinal%20cord%20injury.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20An%20epigenetic%20mechanism%20for%20regenerating%20axons%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Functional%20recovery%20after%20spinal%20cord%20injury%20%28SCI%29%20is%20limited%20by%20lack%20of%20axon%20regeneration%20in%20the%20mature%20nervous%20system.%20However%2C%20recent%20data%20showed%20that%20increasing%20neuronal%20activity%20promoted%20axonal%20regeneration%20after%20SCI%20in%20rodents.%20In%20a%20new%20study%2C%20Hutson%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20et%20al.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20investigated%20the%20mechanisms%20mediating%20activity-dependent%20neuronal%20response%20in%20rodent%20models%20of%20spinal%20cord%20injury.%20Increasing%20neuronal%20activity%20using%20chemical%20or%20behavioral%20approaches%20promoted%20recovery%20through%20Creb-binding%20protein%20%28Cbp%29%5Cu2013mediated%20histone%20acetylation%2C%20and%20using%20a%20small-molecule%20Cbp%20activator%20mimicked%20the%20effects%20of%20increasing%20neuronal%20activity.%20This%20epigenetic%20mechanism%20might%20be%20exploited%20for%20enhancing%20repair%20and%20functional%20recovery%20after%20SCI.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20After%20a%20spinal%20cord%20injury%2C%20axons%20fail%20to%20regenerate%20in%20the%20adult%20mammalian%20central%20nervous%20system%2C%20leading%20to%20permanent%20deficits%20in%20sensory%20and%20motor%20functions.%20Increasing%20neuronal%20activity%20after%20an%20injury%20using%20electrical%20stimulation%20or%20rehabilitation%20can%20enhance%20neuronal%20plasticity%20and%20result%20in%20some%20degree%20of%20recovery%3B%20however%2C%20the%20underlying%20mechanisms%20remain%20poorly%20understood.%20We%20found%20that%20placing%20mice%20in%20an%20enriched%20environment%20before%20an%20injury%20enhanced%20the%20activity%20of%20proprioceptive%20dorsal%20root%20ganglion%20neurons%2C%20leading%20to%20a%20lasting%20increase%20in%20their%20regenerative%20potential.%20This%20effect%20was%20dependent%20on%20Creb-binding%20protein%20%28Cbp%29%5Cu2013mediated%20histone%20acetylation%2C%20which%20increased%20the%20expression%20of%20genes%20associated%20with%20the%20regenerative%20program.%20Intraperitoneal%20delivery%20of%20a%20small-molecule%20activator%20of%20Cbp%20at%20clinically%20relevant%20times%20promoted%20regeneration%20and%20sprouting%20of%20sensory%20and%20motor%20axons%2C%20as%20well%20as%20recovery%20of%20sensory%20and%20motor%20functions%20in%20both%20the%20mouse%20and%20rat%20model%20of%20spinal%20cord%20injury.%20Our%20findings%20showed%20that%20the%20increased%20regenerative%20capacity%20induced%20by%20enhancing%20neuronal%20activity%20is%20mediated%20by%20epigenetic%20reprogramming%20in%20rodent%20models%20of%20spinal%20cord%20injury.%20Understanding%20the%20mechanisms%20underlying%20activity-dependent%20neuronal%20plasticity%20led%20to%20the%20identification%20of%20potential%20molecular%20targets%20for%20improving%20recovery%20after%20spinal%20cord%20injury.%22%2C%22date%22%3A%222019-04-10%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscitranslmed.aaw2064%22%2C%22ISSN%22%3A%221946-6234%2C%201946-6242%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fscitranslmed.aaw2064%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A28%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22NE5Z7GK7%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bourrier%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBourrier%2C%20A.%2C%20Shkorbatova%2C%20P.%2C%20Bonizzato%2C%20M.%2C%20Rey%2C%20E.%2C%20Barraud%2C%20Q.%2C%20Courtine%2C%20G.%2C%20Othmen%2C%20R.%2C%20Reita%2C%20V.%2C%20Bouchiat%2C%20V.%2C%20%26amp%3B%20Delacour%2C%20C.%20%282019%29.%20Monolayer%20Graphene%20Coating%20of%20Intracortical%20Probes%20for%20Long%26%23x2010%3BLasting%20Neural%20Activity%20Monitoring.%20%3Ci%3EAdvanced%20Healthcare%20Materials%3C%5C%2Fi%3E%2C%20%3Ci%3E8%3C%5C%2Fi%3E%2818%29%2C%201801331.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadhm.201801331%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadhm.201801331%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Monolayer%20Graphene%20Coating%20of%20Intracortical%20Probes%20for%20Long%5Cu2010Lasting%20Neural%20Activity%20Monitoring%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Bourrier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polina%22%2C%22lastName%22%3A%22Shkorbatova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Bonizzato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elodie%22%2C%22lastName%22%3A%22Rey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Riadh%22%2C%22lastName%22%3A%22Othmen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valerie%22%2C%22lastName%22%3A%22Reita%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Bouchiat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9cile%22%2C%22lastName%22%3A%22Delacour%22%7D%5D%2C%22abstractNote%22%3A%22The%20invasiveness%20of%20intracortical%20interfaces%20currently%20used%20today%20is%20responsible%20for%20the%20formation%20of%20an%20intense%20immunoresponse%20and%20inflammatory%20reaction%20from%20neural%20cells%20and%20tissues.%20This%20leads%20to%20a%20high%20concentration%20of%20reactive%20glial%20cells%20around%20the%20implant%20site%2C%20creating%20a%20physical%20barrier%20between%20the%20neurons%20and%20the%20recording%20channels.%20Such%20a%20rejection%20of%20foreign%20analog%20interfaces%20causes%20neural%20signals%20to%20fade%20from%20recordings%20which%20become%20flooded%20by%20background%20noise%20after%20a%20few%20weeks.%20Despite%20their%20invasiveness%2C%20those%20devices%20are%20required%20to%20track%20single%20neuron%20activity%20and%20decode%20fine%20sensory%20or%20motor%20commands.%20In%20particular%2C%20such%20quantitative%20and%20long%5Cu2010lasting%20recordings%20of%20individual%20neurons%20are%20crucial%20during%20a%20long%20time%20period%20%28several%20months%29%20to%20restore%20essential%20functions%20of%20the%20cortex%2C%20disrupted%20after%20injuries%2C%20stroke%2C%20or%20neurodegenerative%20diseases.%20To%20overcome%20this%20limitation%2C%20graphene%20and%20related%20materials%20have%20attracted%20numerous%20interests%2C%20as%20they%20gather%20in%20the%20same%20material%20many%20suitable%20properties%20for%20interfacing%20living%20matter%2C%20such%20as%20an%20exceptionally%20high%20neural%20affinity%2C%20diffusion%20barrier%2C%20and%20high%20physical%20robustness.%20In%20this%20work%2C%20the%20neural%20affinity%20of%20a%20graphene%20monolayer%20with%20numerous%20materials%20commonly%20used%20in%20neuroprostheses%20is%20compared%2C%20and%20its%20impact%20on%20the%20performance%20and%20durability%20of%20intracortical%20probes%20is%20investigated.%20For%20that%20purpose%2C%20an%20innovative%20coating%20method%20to%20wrap%203D%20intracortical%20probes%20with%20a%20continuous%20monolayer%20graphene%20is%20developed.%20Experimental%20evidence%20demonstrate%20the%20positive%20impact%20of%20graphene%20on%20the%20bioacceptance%20of%20conventional%20intracortical%20probes%2C%20in%20terms%20of%20detection%20efficiency%20and%20tissues%20responses%2C%20allowing%20real%5Cu2010time%20samplings%20of%20motor%20neuron%20activity%20during%205%20weeks.%20Since%20continuous%20graphene%20coatings%20can%20easily%20be%20implemented%20on%20a%20wide%20range%20of%203D%20surfaces%2C%20this%20study%20further%20motivates%20the%20use%20of%20graphene%20and%20related%20materials%20as%20it%20could%20significantly%20contribute%20to%20reduce%20the%20current%20rejection%20of%20neural%20probes%20currently%20used%20in%20many%20research%20areas%2C%20from%20fundamental%20neurosciences%20to%20medicine%20and%20neuroprostheses.%22%2C%22date%22%3A%2209%5C%2F2019%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fadhm.201801331%22%2C%22ISSN%22%3A%222192-2640%2C%202192-2659%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1002%5C%2Fadhm.201801331%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A27%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22NV9CWLW2%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Skinnider%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESkinnider%2C%20M.%20A.%2C%20Squair%2C%20J.%20W.%2C%20Kathe%2C%20C.%2C%20Anderson%2C%20M.%20A.%2C%20Gautier%2C%20M.%2C%20Matson%2C%20K.%20J.%20E.%2C%20Milano%2C%20M.%2C%20Hutson%2C%20T.%20H.%2C%20Barraud%2C%20Q.%2C%20Phillips%2C%20A.%20A.%2C%20Foster%2C%20L.%20J.%2C%20La%20Manno%2C%20G.%2C%20Levine%2C%20A.%20J.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282021%29.%20Cell%20type%20prioritization%20in%20single-cell%20data.%20%3Ci%3ENature%20Biotechnology%3C%5C%2Fi%3E%2C%20%3Ci%3E39%3C%5C%2Fi%3E%281%29%2C%2030%26%23x2013%3B34.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-020-0605-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-020-0605-1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cell%20type%20prioritization%20in%20single-cell%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Skinnider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaya%20J.%20E.%22%2C%22lastName%22%3A%22Matson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Milano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%20A.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonard%20J.%22%2C%22lastName%22%3A%22Foster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gioele%22%2C%22lastName%22%3A%22La%20Manno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%20J.%22%2C%22lastName%22%3A%22Levine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2201%5C%2F2021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41587-020-0605-1%22%2C%22ISSN%22%3A%221087-0156%2C%201546-1696%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41587-020-0605-1%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A27%3A07Z%22%7D%7D%2C%7B%22key%22%3A%223U66CTZS%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Squair%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESquair%2C%20J.%20W.%2C%20Gautier%2C%20M.%2C%20Mahe%2C%20L.%2C%20Soriano%2C%20J.%20E.%2C%20Rowald%2C%20A.%2C%20Bichat%2C%20A.%2C%20Cho%2C%20N.%2C%20Anderson%2C%20M.%20A.%2C%20James%2C%20N.%20D.%2C%20Gandar%2C%20J.%2C%20Incognito%2C%20A.%20V.%2C%20Schiavone%2C%20G.%2C%20Sarafis%2C%20Z.%20K.%2C%20Laskaratos%2C%20A.%2C%20Bartholdi%2C%20K.%2C%20Demesmaeker%2C%20R.%2C%20Komi%2C%20S.%2C%20Moerman%2C%20C.%2C%20Vaseghi%2C%20B.%2C%20%26%23x2026%3B%20Phillips%2C%20A.%20A.%20%282021%29.%20Neuroprosthetic%20baroreflex%20controls%20haemodynamics%20after%20spinal%20cord%20injury.%20%3Ci%3ENature%3C%5C%2Fi%3E%2C%20%3Ci%3E590%3C%5C%2Fi%3E%287845%29%2C%20308%26%23x2013%3B314.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-020-03180-w%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-020-03180-w%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neuroprosthetic%20baroreflex%20controls%20haemodynamics%20after%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lois%22%2C%22lastName%22%3A%22Mahe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Elaine%22%2C%22lastName%22%3A%22Soriano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Bichat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22Gandar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20V.%22%2C%22lastName%22%3A%22Incognito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zoe%20K.%22%2C%22lastName%22%3A%22Sarafis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achilleas%22%2C%22lastName%22%3A%22Laskaratos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kay%22%2C%22lastName%22%3A%22Bartholdi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Moerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bita%22%2C%22lastName%22%3A%22Vaseghi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berkeley%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Rosentreter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22McCracken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyang%22%2C%22lastName%22%3A%22Kang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vachicouras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ileana%22%2C%22lastName%22%3A%22Jelescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22YunLong%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Buschman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Buse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Denison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Dukelow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecca%22%2C%22lastName%22%3A%22Charbonneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%22%2C%22lastName%22%3A%22Rigby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20K.%22%2C%22lastName%22%3A%22Boyd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20J.%22%2C%22lastName%22%3A%22Millar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%20Martin%22%2C%22lastName%22%3A%22Moraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%20B.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erwan%22%2C%22lastName%22%3A%22Bezard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%20A.%22%2C%22lastName%22%3A%22Phillips%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021-02-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-020-03180-w%22%2C%22ISSN%22%3A%220028-0836%2C%201476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-020-03180-w%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A26%3A52Z%22%7D%7D%2C%7B%22key%22%3A%22HL56PF7U%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bonizzato%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-26%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBonizzato%2C%20M.%2C%20James%2C%20N.%20D.%2C%20Pidpruzhnykova%2C%20G.%2C%20Pavlova%2C%20N.%2C%20Shkorbatova%2C%20P.%2C%20Baud%2C%20L.%2C%20Martinez-Gonzalez%2C%20C.%2C%20Squair%2C%20J.%20W.%2C%20DiGiovanna%2C%20J.%2C%20Barraud%2C%20Q.%2C%20Micera%2C%20S.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282021%29.%20Multi-pronged%20neuromodulation%20intervention%20engages%20the%20residual%20motor%20circuitry%20to%20facilitate%20walking%20in%20a%20rat%20model%20of%20spinal%20cord%20injury.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%201925.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-22137-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-22137-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Multi-pronged%20neuromodulation%20intervention%20engages%20the%20residual%20motor%20circuitry%20to%20facilitate%20walking%20in%20a%20rat%20model%20of%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Bonizzato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Galyna%22%2C%22lastName%22%3A%22Pidpruzhnykova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalia%22%2C%22lastName%22%3A%22Pavlova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Polina%22%2C%22lastName%22%3A%22Shkorbatova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cristina%22%2C%22lastName%22%3A%22Martinez-Gonzalez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jack%22%2C%22lastName%22%3A%22DiGiovanna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20A%20spinal%20cord%20injury%20usually%20spares%20some%20components%20of%20the%20locomotor%20circuitry.%20Deep%20brain%20stimulation%20%28DBS%29%20of%20the%20midbrain%20locomotor%20region%20and%20epidural%20electrical%20stimulation%20of%20the%20lumbar%20spinal%20cord%20%28EES%29%20are%20being%20used%20to%20tap%20into%20this%20spared%20circuitry%20to%20enable%20locomotion%20in%20humans%20with%20spinal%20cord%20injury.%20While%20appealing%2C%20the%20potential%20synergy%20between%20DBS%20and%20EES%20remains%20unknown.%20Here%2C%20we%20report%20the%20synergistic%20facilitation%20of%20locomotion%20when%20DBS%20is%20combined%20with%20EES%20in%20a%20rat%20model%20of%20severe%20contusion%20spinal%20cord%20injury%20leading%20to%20leg%20paralysis.%20However%2C%20this%20synergy%20requires%20high%20amplitudes%20of%20DBS%2C%20which%20triggers%20forced%20locomotion%20associated%20with%20stress%20responses.%20To%20suppress%20these%20undesired%20responses%2C%20we%20link%20DBS%20to%20the%20intention%20to%20walk%2C%20decoded%20from%20cortical%20activity%20using%20a%20robust%2C%20rapidly%20calibrated%20unsupervised%20learning%20algorithm.%20This%20contingency%20amplifies%20the%20supraspinal%20descending%20command%20while%20empowering%20the%20rats%20into%20volitional%20walking.%20However%2C%20the%20resulting%20improvements%20may%20not%20outweigh%20the%20complex%20technological%20framework%20necessary%20to%20establish%20viable%20therapeutic%20conditions.%22%2C%22date%22%3A%222021-03-26%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-021-22137-9%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-021-22137-9%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A26%3A34Z%22%7D%7D%2C%7B%22key%22%3A%225M4KSWQ6%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kathe%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKathe%2C%20C.%2C%20Michoud%2C%20F.%2C%20Sch%26%23xF6%3Bnle%2C%20P.%2C%20Rowald%2C%20A.%2C%20Brun%2C%20N.%2C%20Ravier%2C%20J.%2C%20Furfaro%2C%20I.%2C%20Paggi%2C%20V.%2C%20Kim%2C%20K.%2C%20Soloukey%2C%20S.%2C%20Asboth%2C%20L.%2C%20Hutson%2C%20T.%20H.%2C%20Jelescu%2C%20I.%2C%20Philippides%2C%20A.%2C%20Alwahab%2C%20N.%2C%20Gandar%2C%20J.%2C%20Huber%2C%20D.%2C%20De%20Zeeuw%2C%20C.%20I.%2C%20Barraud%2C%20Q.%2C%20%26%23x2026%3B%20Courtine%2C%20G.%20%282022%29.%20Wireless%20closed-loop%20optogenetics%20across%20the%20entire%20dorsoventral%20spinal%20cord%20in%20mice.%20%3Ci%3ENature%20Biotechnology%3C%5C%2Fi%3E%2C%20%3Ci%3E40%3C%5C%2Fi%3E%282%29%2C%20198%26%23x2013%3B208.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-021-01019-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-021-01019-x%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Wireless%20closed-loop%20optogenetics%20across%20the%20entire%20dorsoventral%20spinal%20cord%20in%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Michoud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Sch%5Cu00f6nle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00e9%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Furfaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Paggi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sadaf%22%2C%22lastName%22%3A%22Soloukey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ileana%22%2C%22lastName%22%3A%22Jelescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Philippides%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noaf%22%2C%22lastName%22%3A%22Alwahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Gandar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Huber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%20I.%22%2C%22lastName%22%3A%22De%20Zeeuw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiuting%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2202%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41587-021-01019-x%22%2C%22ISSN%22%3A%221087-0156%2C%201546-1696%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41587-021-01019-x%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A26%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22TVBWQEZ7%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Squair%20et%20al.%22%2C%22parsedDate%22%3A%222021-09-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESquair%2C%20J.%20W.%2C%20Gautier%2C%20M.%2C%20Kathe%2C%20C.%2C%20Anderson%2C%20M.%20A.%2C%20James%2C%20N.%20D.%2C%20Hutson%2C%20T.%20H.%2C%20Hudelle%2C%20R.%2C%20Qaiser%2C%20T.%2C%20Matson%2C%20K.%20J.%20E.%2C%20Barraud%2C%20Q.%2C%20Levine%2C%20A.%20J.%2C%20La%20Manno%2C%20G.%2C%20Skinnider%2C%20M.%20A.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282021%29.%20Confronting%20false%20discoveries%20in%20single-cell%20differential%20expression.%20%3Ci%3ENature%20Communications%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%281%29%2C%205692.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-25960-2%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41467-021-25960-2%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Confronting%20false%20discoveries%20in%20single-cell%20differential%20expression%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R%5Cu00e9mi%22%2C%22lastName%22%3A%22Hudelle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taha%22%2C%22lastName%22%3A%22Qaiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaya%20J.%20E.%22%2C%22lastName%22%3A%22Matson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%20J.%22%2C%22lastName%22%3A%22Levine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gioele%22%2C%22lastName%22%3A%22La%20Manno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Skinnider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Differential%20expression%20analysis%20in%20single-cell%20transcriptomics%20enables%20the%20dissection%20of%20cell-type-specific%20responses%20to%20perturbations%20such%20as%20disease%2C%20trauma%2C%20or%20experimental%20manipulations.%20While%20many%20statistical%20methods%20are%20available%20to%20identify%20differentially%20expressed%20genes%2C%20the%20principles%20that%20distinguish%20these%20methods%20and%20their%20performance%20remain%20unclear.%20Here%2C%20we%20show%20that%20the%20relative%20performance%20of%20these%20methods%20is%20contingent%20on%20their%20ability%20to%20account%20for%20variation%20between%20biological%20replicates.%20Methods%20that%20ignore%20this%20inevitable%20variation%20are%20biased%20and%20prone%20to%20false%20discoveries.%20Indeed%2C%20the%20most%20widely%20used%20methods%20can%20discover%20hundreds%20of%20differentially%20expressed%20genes%20in%20the%20absence%20of%20biological%20differences.%20To%20exemplify%20these%20principles%2C%20we%20exposed%20true%20and%20false%20discoveries%20of%20differentially%20expressed%20genes%20in%20the%20injured%20mouse%20spinal%20cord.%22%2C%22date%22%3A%222021-09-28%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41467-021-25960-2%22%2C%22ISSN%22%3A%222041-1723%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41467-021-25960-2%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A26%3A02Z%22%7D%7D%2C%7B%22key%22%3A%223NUPTL7W%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Badi%20et%20al.%22%2C%22parsedDate%22%3A%222021-10-27%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBadi%2C%20M.%2C%20Wurth%2C%20S.%2C%20Scarpato%2C%20I.%2C%20Roussinova%2C%20E.%2C%20Losanno%2C%20E.%2C%20Bogaard%2C%20A.%2C%20Delacombaz%2C%20M.%2C%20Borgognon%2C%20S.%2C%20C%26%23x306%3Bvanc%26%23x306%3Bara%2C%20P.%2C%20Fallegger%2C%20F.%2C%20Su%2C%20D.%20K.%2C%20Schmidlin%2C%20E.%2C%20Courtine%2C%20G.%2C%20Bloch%2C%20J.%2C%20Lacour%2C%20S.%20P.%2C%20Stieglitz%2C%20T.%2C%20Rouiller%2C%20E.%20M.%2C%20Capogrosso%2C%20M.%2C%20%26amp%3B%20Micera%2C%20S.%20%282021%29.%20Intrafascicular%20peripheral%20nerve%20stimulation%20produces%20fine%20functional%20hand%20movements%20in%20primates.%20%3Ci%3EScience%20Translational%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%28617%29%2C%20eabg6463.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.abg6463%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.abg6463%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Intrafascicular%20peripheral%20nerve%20stimulation%20produces%20fine%20functional%20hand%20movements%20in%20primates%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marion%22%2C%22lastName%22%3A%22Badi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Wurth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilaria%22%2C%22lastName%22%3A%22Scarpato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evgenia%22%2C%22lastName%22%3A%22Roussinova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elena%22%2C%22lastName%22%3A%22Losanno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Bogaard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maude%22%2C%22lastName%22%3A%22Delacombaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Borgognon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22C%5Cu0306vanc%5Cu0306ara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20K.%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%22%2C%22lastName%22%3A%22Schmidlin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Stieglitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20M.%22%2C%22lastName%22%3A%22Rouiller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%5D%2C%22abstractNote%22%3A%22Intrafascicular%20stimulation%20evokes%20precise%20and%20functional%20hand%20movements%20in%20monkeys%2C%20suggesting%20clinical%20opportunities%20for%20people%20with%20hand%20paralysis.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20It%20is%20TIME%20to%20move%20your%20hand%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Upper%20limb%20paralysis%20can%20develop%20after%20spinal%20cord%20injury%20or%20stroke.%20Electrical%20stimulation%20has%20been%20used%20to%20partially%20restore%20hand%20movements%3B%20however%2C%20current%20approaches%20using%20surface%20or%20intramuscular%20stimulation%20require%20challenging%20surgeries%20and%5C%2For%20have%20limited%20efficacy%20and%20are%20associated%20with%20important%20adverse%20effects.%20Here%2C%20Badi%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20et%20al.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20developed%20an%20intraneural%20transverse%20intrafascicular%20multichannel%20electrode%20%28TIME%29%20system%2C%20composed%20of%20two%20electrodes%20for%20stimulation%20of%20the%20median%20and%20radial%20nerve%2C%20that%20was%20able%20to%20restore%20hand%20movements%20in%20primates.%20In%20a%20proof-of-principle%20experiment%2C%20one%20paralyzed%20monkey%20was%20able%20to%20perform%20hand%20movements%20using%20a%20brain-controlled%20TIME.%20Intrafascicular%20stimulation%20might%20be%20used%20for%20generating%20and%20allowing%20fine%20hand%20movements%20in%20paralyzed%20patients.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Restoring%20dexterous%20hand%20control%20is%20critical%20for%20people%20with%20paralysis.%20Approaches%20based%20on%20surface%20or%20intramuscular%20stimulation%20provide%20limited%20finger%20control%2C%20generate%20insufficient%20force%20to%20recover%20functional%20movements%2C%20and%20require%20numerous%20electrodes.%20Here%2C%20we%20show%20that%20intrafascicular%20peripheral%20electrodes%20could%20produce%20functional%20grasps%20and%20sustained%20forces%20in%20three%20monkeys.%20We%20designed%20an%20intrafascicular%20implantable%20electrode%20targeting%20the%20motor%20fibers%20of%20the%20median%20and%20radial%20nerves.%20Our%20interface%20selectively%20and%20reliably%20activated%20extrinsic%20and%20intrinsic%20hand%20muscles%2C%20generating%20multiple%20functional%20grips%2C%20hand%20opening%2C%20and%20sustained%20contraction%20forces%20for%20up%20to%202%20months.%20We%20extended%20those%20results%20to%20a%20behaving%20monkey%20with%20transient%20hand%20paralysis%20and%20used%20intracortical%20signals%20to%20control%20simple%20stimulation%20protocols%20that%20enabled%20this%20animal%20to%20perform%20a%20functional%20grasping%20task.%20Our%20findings%20show%20that%20just%20two%20intrafascicular%20electrodes%20can%20generate%20a%20rich%20portfolio%20of%20dexterous%20and%20functional%20hand%20movements%20with%20important%20implications%20for%20clinical%20applicability.%22%2C%22date%22%3A%222021-10-27%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscitranslmed.abg6463%22%2C%22ISSN%22%3A%221946-6234%2C%201946-6242%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fscitranslmed.abg6463%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A25%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22UF9L2AAC%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Barra%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBarra%2C%20B.%2C%20Conti%2C%20S.%2C%20Perich%2C%20M.%20G.%2C%20Zhuang%2C%20K.%2C%20Schiavone%2C%20G.%2C%20Fallegger%2C%20F.%2C%20Galan%2C%20K.%2C%20James%2C%20N.%20D.%2C%20Barraud%2C%20Q.%2C%20Delacombaz%2C%20M.%2C%20Kaeser%2C%20M.%2C%20Rouiller%2C%20E.%20M.%2C%20Milekovic%2C%20T.%2C%20Lacour%2C%20S.%2C%20Bloch%2C%20J.%2C%20Courtine%2C%20G.%2C%20%26amp%3B%20Capogrosso%2C%20M.%20%282022%29.%20Epidural%20electrical%20stimulation%20of%20the%20cervical%20dorsal%20roots%20restores%20voluntary%20upper%20limb%20control%20in%20paralyzed%20monkeys.%20%3Ci%3ENature%20Neuroscience%3C%5C%2Fi%3E%2C%20%3Ci%3E25%3C%5C%2Fi%3E%287%29%2C%20924%26%23x2013%3B934.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-022-01106-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-022-01106-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Epidural%20electrical%20stimulation%20of%20the%20cervical%20dorsal%20roots%20restores%20voluntary%20upper%20limb%20control%20in%20paralyzed%20monkeys%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Barra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Conti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20G.%22%2C%22lastName%22%3A%22Perich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katie%22%2C%22lastName%22%3A%22Zhuang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katia%22%2C%22lastName%22%3A%22Galan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maude%22%2C%22lastName%22%3A%22Delacombaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M%5Cu00e9lanie%22%2C%22lastName%22%3A%22Kaeser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20M.%22%2C%22lastName%22%3A%22Rouiller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomislav%22%2C%22lastName%22%3A%22Milekovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2207%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41593-022-01106-5%22%2C%22ISSN%22%3A%221097-6256%2C%201546-1726%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41593-022-01106-5%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A25%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22CDH4FGHN%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pasquini%20et%20al.%22%2C%22parsedDate%22%3A%222022-03-30%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPasquini%2C%20M.%2C%20James%2C%20N.%20D.%2C%20Dewany%2C%20I.%2C%20Coen%2C%20F.-V.%2C%20Cho%2C%20N.%2C%20Lai%2C%20S.%2C%20Anil%2C%20S.%2C%20Carpaneto%2C%20J.%2C%20Barraud%2C%20Q.%2C%20Lacour%2C%20S.%20P.%2C%20Micera%2C%20S.%2C%20%26amp%3B%20Courtine%2C%20G.%20%282022%29.%20Preclinical%20upper%20limb%20neurorobotic%20platform%20to%20assess%2C%20rehabilitate%2C%20and%20develop%20therapies.%20%3Ci%3EScience%20Robotics%3C%5C%2Fi%3E%2C%20%3Ci%3E7%3C%5C%2Fi%3E%2864%29%2C%20eabk2378.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscirobotics.abk2378%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscirobotics.abk2378%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Preclinical%20upper%20limb%20neurorobotic%20platform%20to%20assess%2C%20rehabilitate%2C%20and%20develop%20therapies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Pasquini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inssia%22%2C%22lastName%22%3A%22Dewany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florent-Val%5Cu00e9ry%22%2C%22lastName%22%3A%22Coen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Lai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Selin%22%2C%22lastName%22%3A%22Anil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jacopo%22%2C%22lastName%22%3A%22Carpaneto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Numerous%20neurorehabilitative%2C%20neuroprosthetic%2C%20and%20repair%20interventions%20aim%20to%20address%20the%20consequences%20of%20upper%20limb%20impairments%20after%20neurological%20disorders.%20Although%20these%20therapies%20target%20widely%20different%20mechanisms%2C%20they%20share%20the%20common%20need%20for%20a%20preclinical%20platform%20that%20supports%20the%20development%2C%20assessment%2C%20and%20understanding%20of%20the%20therapy.%20Here%2C%20we%20introduce%20a%20neurorobotic%20platform%20for%20rats%20that%20meets%20these%20requirements.%20A%20four-degree-of-freedom%20end%20effector%20is%20interfaced%20with%20the%20rat%5Cu2019s%20wrist%2C%20enabling%20unassisted%20to%20fully%20assisted%20execution%20of%20natural%20reaching%20and%20retrieval%20movements%20covering%20the%20entire%20body%20workspace.%20Multimodal%20recording%20capabilities%20permit%20precise%20quantification%20of%20upper%20limb%20movement%20recovery%20after%20spinal%20cord%20injury%20%28SCI%29%2C%20which%20allowed%20us%20to%20uncover%20adaptations%20in%20corticospinal%20tract%20neuron%20dynamics%20underlying%20this%20recovery.%20Personalized%20movement%20assistance%20supported%20early%20neurorehabilitation%20that%20improved%20recovery%20after%20SCI.%20Last%2C%20the%20platform%20provided%20a%20well-controlled%20and%20practical%20environment%20to%20develop%20an%20implantable%20spinal%20cord%20neuroprosthesis%20that%20improved%20upper%20limb%20function%20after%20SCI.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20A%20robotic%20platform%20with%20four%20DOFs%20facilitates%20the%20assessment%2C%20treatment%2C%20and%20rehabilitation%20of%20upper%20limb%20deficits%20in%20rats.%22%2C%22date%22%3A%222022-03-30%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscirobotics.abk2378%22%2C%22ISSN%22%3A%222470-9476%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fscirobotics.abk2378%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A24%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22D4L5HWFN%22%2C%22library%22%3A%7B%22id%22%3A5649449%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kathe%20et%20al.%22%2C%22parsedDate%22%3A%222022-11-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKathe%2C%20C.%2C%20Skinnider%2C%20M.%20A.%2C%20Hutson%2C%20T.%20H.%2C%20Regazzi%2C%20N.%2C%20Gautier%2C%20M.%2C%20Demesmaeker%2C%20R.%2C%20Komi%2C%20S.%2C%20Ceto%2C%20S.%2C%20James%2C%20N.%20D.%2C%20Cho%2C%20N.%2C%20Baud%2C%20L.%2C%20Galan%2C%20K.%2C%20Matson%2C%20K.%20J.%20E.%2C%20Rowald%2C%20A.%2C%20Kim%2C%20K.%2C%20Wang%2C%20R.%2C%20Minassian%2C%20K.%2C%20Prior%2C%20J.%20O.%2C%20Asboth%2C%20L.%2C%20%26%23x2026%3B%20Courtine%2C%20G.%20%282022%29.%20The%20neurons%20that%20restore%20walking%20after%20paralysis.%20%3Ci%3ENature%3C%5C%2Fi%3E%2C%20%3Ci%3E611%3C%5C%2Fi%3E%287936%29%2C%20540%26%23x2013%3B547.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-022-05385-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-022-05385-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20neurons%20that%20restore%20walking%20after%20paralysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Skinnider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Regazzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%22%2C%22lastName%22%3A%22Ceto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katia%22%2C%22lastName%22%3A%22Galan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaya%20J.%20E.%22%2C%22lastName%22%3A%22Matson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruijia%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20O.%22%2C%22lastName%22%3A%22Prior%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%20J.%22%2C%22lastName%22%3A%22Levine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20spinal%20cord%20injury%5Cu00a0interrupts%20pathways%20from%20the%20brain%20and%20brainstem%20that%20project%20to%20the%20lumbar%20spinal%20cord%2C%20leading%20to%20paralysis.%20Here%20we%20show%20that%20spatiotemporal%20epidural%20electrical%20stimulation%20%28EES%29%20of%20the%20lumbar%20spinal%20cord%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%201%5Cu20133%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20applied%20during%20neurorehabilitation%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%204%2C5%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%28EES%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20REHAB%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20restored%20walking%20in%20nine%20individuals%20with%20chronic%20spinal%20cord%20injury.%20This%20recovery%20involved%20a%20reduction%20in%20neuronal%20activity%20in%20the%20lumbar%20spinal%20cord%20of%20humans%20during%20walking.%20We%20hypothesized%20that%20this%20unexpected%20reduction%20reflects%20activity-dependent%20selection%20of%20specific%20neuronal%20subpopulations%20that%20become%20essential%20for%20a%20patient%5Cu00a0to%20walk%20after%20spinal%20cord%20injury.%20To%20identify%20these%20putative%20neurons%2C%20we%20modelled%20the%20technological%20and%20therapeutic%20features%20underlying%20EES%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20REHAB%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20mice.%20We%20applied%20single-nucleus%20RNA%20sequencing%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%206%5Cu20139%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%20spatial%20transcriptomics%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%2010%2C11%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20to%20the%20spinal%20cords%20of%20these%20mice%20to%20chart%20a%20spatially%20resolved%20molecular%20atlas%20of%20recovery%20from%20paralysis.%20We%20then%20employed%5Cu00a0cell%20type%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%2012%2C13%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%20spatial%20prioritization%20to%20identify%20the%20neurons%20involved%20in%20the%20recovery%20of%20walking.%20A%20single%20population%20of%20excitatory%20interneurons%20nested%20within%20intermediate%20laminae%5Cu00a0emerged.%20Although%20these%20neurons%20are%20not%20required%20for%20walking%20before%20spinal%20cord%20injury%2C%20we%20demonstrate%20that%20they%20are%20essential%20for%20the%5Cu00a0recovery%20of%20walking%20with%20EES%20following%20spinal%20cord%20injury.%20Augmenting%20the%20activity%20of%20these%20neurons%20phenocopied%20the%20recovery%20of%20walking%20enabled%20by%20EES%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20REHAB%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20whereas%20ablating%20them%20prevented%20the%20recovery%20of%20walking%20that%20occurs%20spontaneously%20after%20moderate%20spinal%20cord%20injury.%20We%20thus%20identified%20a%20recovery-organizing%20neuronal%20subpopulation%20that%20is%20necessary%20and%20sufficient%20to%20regain%20walking%20after%20paralysis.%20Moreover%2C%20our%20methodology%20establishes%20a%20framework%20for%5Cu00a0using%20molecular%20cartography%5Cu00a0to%20identify%20the%20neurons%20that%20produce%20complex%20behaviours.%22%2C%22date%22%3A%222022-11-17%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-022-05385-7%22%2C%22ISSN%22%3A%220028-0836%2C%201476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-022-05385-7%22%2C%22collections%22%3A%5B%22QWCYR4J9%22%2C%22VH52CPEQ%22%5D%2C%22dateModified%22%3A%222024-09-09T08%3A24%3A16Z%22%7D%7D%5D%7D
Beanato, E., Moon, H.-J., Windel, F., Vassiliadis, P., Wessel, M. J., Popa, T., Pauline, M., Neufeld, E., De Falco, E., Gauthier, B., Steiner, M., Blanke, O., & Hummel, F. C. (2024). Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans. Science Advances, 10(44), eado4103. https://doi.org/10.1126/sciadv.ado4103
Meyer, N. H., Gauthier, B., Stampacchia, S., Boscheron, J., Babo-Rebelo, M., Potheegadoo, J., Herbelin, B., Lance, F., Alvarez, V., Franc, E., Esposito, F., Morais Lacerda, M., & Blanke, O. (2024). Embodiment in episodic memory through premotor-hippocampal coupling. Communications Biology, 7(1), 1111. https://doi.org/10.1038/s42003-024-06757-7
Mancini, V., Saleh, M. G., Delavari, F., Bagautdinova, J., & Eliez, S. (2023). Excitatory/Inhibitory Imbalance Underlies Hippocampal Atrophy in Individuals With 22q11.2 Deletion Syndrome With Psychotic Symptoms. Biological Psychiatry, 94(7), 569–579. https://doi.org/10.1016/j.biopsych.2023.03.021
Latrèche, C., Mancini, V., Rochas, V., Maeder, J., Cantonas, L. M., Férat, V., Schneider, M., Michel, C. M., & Eliez, S. (2024). Using transcranial alternating current stimulation to enhance working memory skills in youths with 22q11.2 deletion syndrome: A randomized double-blind sham-controlled study. Psychiatry Research, 335, 115835. https://doi.org/10.1016/j.psychres.2024.115835
Liverani, M. C., Siffredi, V., Mikneviciute, G., Mazza, E., Ha-Vinh Leuchter, R., Hüppi, P. S., Borradori Tolsa, C., & Gentaz, E. (2024). “Vis-à-Vis Training” to Improve Emotional and Executive Competences in Very Preterm Children: A Pilot Study and Randomised Controlled Trial. Children, 11(8), 956. https://doi.org/10.3390/children11080956
Siffredi, V., Liverani, M. C., Fernandez, N., Freitas, L. G. A., Borradori Tolsa, C., Van De Ville, D., Hüppi, P. S., & Ha‐Vinh Leuchter, R. (2024). Impact of a mindfulness‐based intervention on neurobehavioral functioning and its association with large‐scale brain networks in preterm young adolescents. Psychiatry and Clinical Neurosciences, 78(7), 416–425. https://doi.org/10.1111/pcn.13675
Siffredi, V., Liverani, M. C., Borradori-Tolsa, C., Leuchter, R. H.-V., Thiran, J.-P., Hüppi, P. S., & Fischi-Gómez, E. (2023). Cortical alterations after very preterm birth and the association with socio-emotional abilities from childhood to early adolescence. Cerebral Cortex, 33(14), 9117–9129. https://doi.org/10.1093/cercor/bhad187
Siffredi, V., Liverani, M. C., Van De Ville, D., Freitas, L. G. A., Borradori Tolsa, C., Hüppi, P. S., & Ha-Vinh Leuchter, R. (2023). The effect of mindfulness-based intervention on neurobehavioural functioning and its association with white-matter microstructural changes in preterm young adolescents. Scientific Reports, 13(1), 2010. https://doi.org/10.1038/s41598-023-29205-8
Meyer, N. H., Gauthier, B., Stampacchia, S., Boscheron, J., Babo-Rebelo, M., Potheegadoo, J., Herbelin, B., Lance, F., Alvarez, V., Franc, E., Esposito, F., Morais Lacerda, M., & Blanke, O. (2024). Embodiment in episodic memory through premotor-hippocampal coupling. Communications Biology, 7(1), 1111. https://doi.org/10.1038/s42003-024-06757-7
Dhanis, H., Gninenko, N., Morgenroth, E., Potheegadoo, J., Rognini, G., Faivre, N., Blanke, O., & Van De Ville, D. (2024). Real-time fMRI neurofeedback modulates induced hallucinations and underlying brain mechanisms. Communications Biology, 7(1), 1120. https://doi.org/10.1038/s42003-024-06842-x
Mariello, M., Rosenthal, J. D., Cecchetti, F., Gao, M., Skrivervik, A. K., Leterrier, Y., & Lacour, S. P. (2024). Wireless, battery-free, and real-time monitoring of water permeation across thin-film encapsulation. Nature Communications, 15(1), 7443. https://doi.org/10.1038/s41467-024-51247-3
Wu, K., Mariello, M., Leterrier, Y., & Lacour, S. P. (2024). Optical Monitoring of Water Side Permeation in Thin Film Encapsulation. Advanced Materials, 36(24), 2310201. https://doi.org/10.1002/adma.202310201
Fallegger, F., Trouillet, A., Coen, F.-V., Schiavone, G., & Lacour, S. P. (2023). A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces. APL Bioengineering, 7(3), 036109. https://doi.org/10.1063/5.0152509
Song, S., Fallegger, F., Trouillet, A., Kim, K., & Lacour, S. P. (2023). Deployment of an electrocorticography system with a soft robotic actuator. Science Robotics, 8(78), eadd1002. https://doi.org/10.1126/scirobotics.add1002
Fallegger, F., Trouillet, A., & Lacour, S. P. (2023). Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs. Journal of Visualized Experiments, 193, 64997. https://doi.org/10.3791/64997
Borda, E., Medagoda, D. I., Airaghi Leccardi, M. J. I., Zollinger, E. G., & Ghezzi, D. (2023). Conformable neural interface based on off-stoichiometry thiol-ene-epoxy thermosets. Biomaterials, 293, 121979. https://doi.org/10.1016/j.biomaterials.2022.121979
Nayir, S., Lacour, S. P., & Kucera, J. P. (2022). Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures. The Journal of Physiology, 600(14), 3287–3312. https://doi.org/10.1113/JP283083
Kim, K., Van Gompel, M., Wu, K., Schiavone, G., Carron, J., Bourgeois, F., Lacour, S. P., & Leterrier, Y. (2021). Extended Barrier Lifetime of Partially Cracked Organic/Inorganic Multilayers for Compliant Implantable Electronics. Small, 17(40), 2103039. https://doi.org/10.1002/smll.202103039
Schiavone, G., Vachicouras, N., Vyza, Y., & Lacour, S. P. (2021). Dimensional scaling of thin-film stimulation electrode systems in translational research. Journal of Neural Engineering, 18(4), 046054. https://doi.org/10.1088/1741-2552/abf607
Moon, H.-J., Gauthier, B., Park, H.-D., Faivre, N., & Blanke, O. (2022). Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex. Communications Biology, 5(1), 406. https://doi.org/10.1038/s42003-022-03361-5
Li, A., Feitelberg, J., Saini, A. P., Höchenberger, R., & Scheltienne, M. (2022). MNE-ICALabel: Automatically annotating ICA components with ICLabel in Python. Journal of Open Source Software, 7(76), 4484. https://doi.org/10.21105/joss.04484
Sanches, E., Ho, D., Van De Looij, Y., Aebi Toulotte, A., Baud, L., Bouteldja, F., Barraud, Q., Araneda, R., Bleyenheuft, Y., Brochard, S., Kathe, C., Courtine, G., & Sizonenko, S. (2024). Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy. Brain, Behavior, and Immunity, 121, 303–316. https://doi.org/10.1016/j.bbi.2024.08.005
Ho, D., Sanches, E. F., & Sizonenko, S. V. (2022). Early neurodevelopmental reflex impairments in a rodent model of cerebral palsy. International Journal of Developmental Neuroscience, 82(8), 814–822. https://doi.org/10.1002/jdn.10235
D’Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022). Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell, 21(8), e13662. https://doi.org/10.1111/acel.13662
Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022). Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3(5), 100633. https://doi.org/10.1016/j.xcrm.2022.100633
D’Amico, D., Fouassier, A., Faitg, J., Hennighausen, N., Brandt, M., Konstantopoulos, D., Rinsch, C., & Singh, A. (2023). Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials. https://doi.org/10.1101/2023.06.16.23291378
Liu, S., Faitg, J., Tissot, C., Konstantopoulos, D., Laws, R., Bourdier, G., Andreux, P. A., Davey, T., Singh, A., Rinsch, C., Marcinek, D. J., & D’Amico, D. (2023). Urolithin A induces cardioprotection and enhanced mitochondrial quality during natural aging and heart failure. https://doi.org/10.1101/2023.08.22.554375
Finsterwald, C., Dias, S., Magistretti, P. J., & Lengacher, S. (2021). Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism. Frontiers in Pharmacology, 12, 653842. https://doi.org/10.3389/fphar.2021.653842
Sipion, M., Ferreira, F. M., Scholler, J., Brana, C., Gora, M., Kouvas, G., Barthet, G., & Sobolewski, A. (2023). A randomized, blinded study of photobiomodulation in a mouse model of Alzheimer’s disease showed no preventive effect. Scientific Reports, 13(1), 19828. https://doi.org/10.1038/s41598-023-47039-2
Ye, S., Lauer, J., Zhou, M., Mathis, A., & Mathis, M. W. (2023). AmadeusGPT: a natural language interface for interactive animal behavioral analysis. https://doi.org/10.48550/ARXIV.2307.04858
Ye, S., Filippova, A., Lauer, J., Schneider, S., Vidal, M., Qiu, T., Mathis, A., & Mathis, M. W. (2024). SuperAnimal pretrained pose estimation models for behavioral analysis. Nature Communications, 15(1), 5165. https://doi.org/10.1038/s41467-024-48792-2
Achard, C., Kousi, T., Frey, M., Vidal, M., Paychère, Y., Hofmann, C., Iqbal, A., Hausmann, S. B., Pagès, S., & Mathis, M. W. (2024). CellSeg3D: self-supervised 3D cell segmentation for microscopy. https://doi.org/10.1101/2024.05.17.594691
Vachicouras, N., Tarabichi, O., Kanumuri, V. V., Tringides, C. M., Macron, J., Fallegger, F., Thenaisie, Y., Epprecht, L., McInturff, S., Qureshi, A. A., Paggi, V., Kuklinski, M. W., Brown, M. C., Lee, D. J., & Lacour, S. P. (2019). Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants. Science Translational Medicine, 11(514), eaax9487. https://doi.org/10.1126/scitranslmed.aax9487
Shur, M., Fallegger, F., Pirondini, E., Roux, A., Bichat, A., Barraud, Q., Courtine, G., & Lacour, S. P. (2020). Soft Printable Electrode Coating for Neural Interfaces. ACS Applied Bio Materials, 3(7), 4388–4397. https://doi.org/10.1021/acsabm.0c00401
Paggi, V., Fallegger, F., Serex, L., Rizzo, O., Galan, K., Giannotti, A., Furfaro, I., Zinno, C., Bernini, F., Micera, S., & Lacour, S. P. (2024). A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation. Bioelectronic Medicine, 10(1), 6. https://doi.org/10.1186/s42234-023-00137-y
Von Zitzewitz, J., Asboth, L., Fumeaux, N., Hasse, A., Baud, L., Vallery, H., & Courtine, G. (2016). A neurorobotic platform for locomotor prosthetic development in rats and mice. Journal of Neural Engineering, 13(2), 026007. https://doi.org/10.1088/1741-2560/13/2/026007
Wurth, S., Capogrosso, M., Raspopovic, S., Gandar, J., Federici, G., Kinany, N., Cutrone, A., Piersigilli, A., Pavlova, N., Guiet, R., Taverni, G., Rigosa, J., Shkorbatova, P., Navarro, X., Barraud, Q., Courtine, G., & Micera, S. (2017). Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes. Biomaterials, 122, 114–129. https://doi.org/10.1016/j.biomaterials.2017.01.014
Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., Batti, L., Pagès, S., Kreider, J., Schneider, B. L., Barraud, Q., & Courtine, G. (2018). Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nature Neuroscience, 21(4), 576–588. https://doi.org/10.1038/s41593-018-0093-5
Bonizzato, M., Pidpruzhnykova, G., DiGiovanna, J., Shkorbatova, P., Pavlova, N., Micera, S., & Courtine, G. (2018). Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury. Nature Communications, 9(1), 3015. https://doi.org/10.1038/s41467-018-05282-6
Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., De Virgiliis, F., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., Danzi, M. C., Medrano-Fernandez, A., Lopez-Atalaya, J. P., Boutillier, A. L., Sinha, S. H., Singh, A. K., Chaturbedy, P., Moon, L. D. F., Kundu, T. K., … Di Giovanni, S. (2019). Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Science Translational Medicine, 11(487), eaaw2064. https://doi.org/10.1126/scitranslmed.aaw2064
Bourrier, A., Shkorbatova, P., Bonizzato, M., Rey, E., Barraud, Q., Courtine, G., Othmen, R., Reita, V., Bouchiat, V., & Delacour, C. (2019). Monolayer Graphene Coating of Intracortical Probes for Long‐Lasting Neural Activity Monitoring. Advanced Healthcare Materials, 8(18), 1801331. https://doi.org/10.1002/adhm.201801331
Skinnider, M. A., Squair, J. W., Kathe, C., Anderson, M. A., Gautier, M., Matson, K. J. E., Milano, M., Hutson, T. H., Barraud, Q., Phillips, A. A., Foster, L. J., La Manno, G., Levine, A. J., & Courtine, G. (2021). Cell type prioritization in single-cell data. Nature Biotechnology, 39(1), 30–34. https://doi.org/10.1038/s41587-020-0605-1
Squair, J. W., Gautier, M., Mahe, L., Soriano, J. E., Rowald, A., Bichat, A., Cho, N., Anderson, M. A., James, N. D., Gandar, J., Incognito, A. V., Schiavone, G., Sarafis, Z. K., Laskaratos, A., Bartholdi, K., Demesmaeker, R., Komi, S., Moerman, C., Vaseghi, B., … Phillips, A. A. (2021). Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature, 590(7845), 308–314. https://doi.org/10.1038/s41586-020-03180-w
Bonizzato, M., James, N. D., Pidpruzhnykova, G., Pavlova, N., Shkorbatova, P., Baud, L., Martinez-Gonzalez, C., Squair, J. W., DiGiovanna, J., Barraud, Q., Micera, S., & Courtine, G. (2021). Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury. Nature Communications, 12(1), 1925. https://doi.org/10.1038/s41467-021-22137-9
Kathe, C., Michoud, F., Schönle, P., Rowald, A., Brun, N., Ravier, J., Furfaro, I., Paggi, V., Kim, K., Soloukey, S., Asboth, L., Hutson, T. H., Jelescu, I., Philippides, A., Alwahab, N., Gandar, J., Huber, D., De Zeeuw, C. I., Barraud, Q., … Courtine, G. (2022). Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice. Nature Biotechnology, 40(2), 198–208. https://doi.org/10.1038/s41587-021-01019-x
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., Levine, A. J., La Manno, G., Skinnider, M. A., & Courtine, G. (2021). Confronting false discoveries in single-cell differential expression. Nature Communications, 12(1), 5692. https://doi.org/10.1038/s41467-021-25960-2
Badi, M., Wurth, S., Scarpato, I., Roussinova, E., Losanno, E., Bogaard, A., Delacombaz, M., Borgognon, S., C̆vanc̆ara, P., Fallegger, F., Su, D. K., Schmidlin, E., Courtine, G., Bloch, J., Lacour, S. P., Stieglitz, T., Rouiller, E. M., Capogrosso, M., & Micera, S. (2021). Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates. Science Translational Medicine, 13(617), eabg6463. https://doi.org/10.1126/scitranslmed.abg6463
Barra, B., Conti, S., Perich, M. G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N. D., Barraud, Q., Delacombaz, M., Kaeser, M., Rouiller, E. M., Milekovic, T., Lacour, S., Bloch, J., Courtine, G., & Capogrosso, M. (2022). Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys. Nature Neuroscience, 25(7), 924–934. https://doi.org/10.1038/s41593-022-01106-5
Pasquini, M., James, N. D., Dewany, I., Coen, F.-V., Cho, N., Lai, S., Anil, S., Carpaneto, J., Barraud, Q., Lacour, S. P., Micera, S., & Courtine, G. (2022). Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies. Science Robotics, 7(64), eabk2378. https://doi.org/10.1126/scirobotics.abk2378
Kathe, C., Skinnider, M. A., Hutson, T. H., Regazzi, N., Gautier, M., Demesmaeker, R., Komi, S., Ceto, S., James, N. D., Cho, N., Baud, L., Galan, K., Matson, K. J. E., Rowald, A., Kim, K., Wang, R., Minassian, K., Prior, J. O., Asboth, L., … Courtine, G. (2022). The neurons that restore walking after paralysis. Nature, 611(7936), 540–547. https://doi.org/10.1038/s41586-022-05385-7